Somatropin
Also known as: Human Growth hormone
Somatropin is a growth hormone. Somatropin is used in the treatment of growth hormone deficiecy in children or for the treatment of HIV-related weight loss.
Primary Characteristics
Somatropin is also known as Human Growth hormone.
It is of Synthetic origin and belongs to Amino Acid.
It belongs to Growth hormone agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 22000 · pKa: 6.0 - 7.5 · Non-proprietary name: Somatropin.
Pharmacokinetics
Distribution: Somatropin has a volume of distribution is 0.05 l/kg. plasma protein binding is variable.
Elimination: plasma half-life is 9 +/- 3.5 min (alpha), 30.7 +/- 10.8 min (beta), renal excretion is < 0.01 %.
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Indications
Somatropin is primarily indicated in conditions like Adult growth hormone deficiency, Chronic renal failure, Deficiency of growth hormone in children, Gonadal dysgenesis (turner syndrome), Growth hormone deficiency, Severe chronic neutropenia, Turners syndrome.
Contraindications
Somatropin is contraindicated in conditions like Diabetes mellitus.
Dosage
Somatropin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.018 IU/ kg | 0.018 IU/ kg | — | SC | As a single dose. For the treatment of growth failure or growth hormon deficiency. Maximum dose 0.0375 IU/kg/day. |
| 4.75 mg | 4.75 mg | Every 24h | SC | Doses vary according to body weight. |
| Paediatric Dosage (20kg) | ||||
| 0.199 IU/kg | 0.199 IU/kg | Every 8h | Intra Muscular | - |
| 0.099 IU/kg | 0.099 IU/kg | Every 4h | Subcutaneous | - |
| Neonatal Dosage (3kg) | ||||
| 0.199 IU/kg | 0.199 IU/kg | Every 8h | Intra Muscular | - |
| 0.099 IU/kg | 0.099 IU/kg | Every 4h | Subcutaneous | - |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Somatropin is known to cause more or less tolerable side effects which are usually transient. These include Arthralgia, Edema, Lipoatrophy, Urticaria.
Warnings / Precautions
Interference in Pathology
Somatropin may interfere in the diagnosis of Immunoassay of Endogenous Growth Hormone .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.10 — Growth hormones