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Sodium Cromoglycate

Also known as: Sodium Cromoglicate

Drug #663

Sodium Cromoglycate acts by blocking the allergic mechanism. itused as a preventive treatment for asthma, hay fever and conjuctivitis caused by allergy. italso used in ulcerative colitis. Sodium Cromoglycate can be given orally, by inhalation of powder or topically in eye.

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Primary Characteristics

Sodium Cromoglycate is also known as Sodium Cromoglicate.

It is of Synthetic origin and belongs to Chromene.

It is also classified under Opthalmic Products .

Molecular Weight: 512.3 · pKa: 1.9 · Solubility in Water: 1 in 20 · Solubility in Alcohol: Insoluble · Non-proprietary name: Sodium Cromoglycate.

Molecular structure of Sodium Cromoglycate

Pharmacokinetics

Absorption: Sodium Cromoglycate has an oral bioavailability is 0.5% (±0.5%).

Distribution: Sodium Cromoglycate has a volume of distribution is 0.32 l/kg. plasma protein binding is 57 - 69 %.

Elimination: plasma half-life is 60 - 90 min, renal excretion is 50 %.

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Indications

Sodium Cromoglycate is primarily indicated in conditions like Allergy, Asthma, Conjuctivitis, Food allergy, Metastatic melanoma, Perennial rhinitis, Prophylaxis of asthma, Reduction in the duration of neutropenia following bone marrow transplantation, Reduction of bone damage, Seasonal allergic rhinitis.

Contraindications

None recorded.

Dosage

Sodium Cromoglycate's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
10 mg10 mgEvery 6hInhalationalIncreased in severe cases to 6 times daily
1.5 mg1.5 mgEvery 6hOphthalmic -
3 %3 %—OphthalmicAs Required.To be given as drops.
Paediatric Dosage (20kg)
1.5 mg1.5 mgEvery 6hOpthalmic -
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sodium Cromoglycate produces potentially life-threatening effects which include Bronchospasm . Careful monitoring is needed with proper medical management.

Sodium Cromoglycate is known to cause more or less tolerable side effects which are usually transient. These include Local irritation.

Warnings / Precautions

Withdrawal of sodium cromoglycate may lead to recurrence of the symptoms of asthma. If withdrawal is necessary, it has been suggested that the dose should be reduce gradually over a period of one week.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Drops
0.2 %w/v
Eye Drops
0.4 %w/v2 %w/v4 %w/v
Nasal Spray
2 %w/v4 %w/v

Multi-Ingredient Combinations

Eye Drops
4 %w/v
Nasal Spray
2 %w/v

Storage Conditions

Sodium Cromoglycate should be stored Eye Drops.

Drug Classification

  1. 1.21.2.3 — Non steroidal anti-inflammatory drugs (NSAIDs)
  2. 2.21.6 — Non-specific anticonjunctivitis preparations
  3. 3.25.1.2 — Inhalants
  4. 4.25.4 — Nasal preparations

Manufacturers