Sodium Chloride

Drug #662

Sodium Chloride is a common table salt, soluble in water and found widely distributed over the earth and in sea water. Sodium Chloride is a necessary constituent of the body and consequently of the diet. Sodium Chloride is used to replace lost fluids of body. its hyperosmolar solution is used as an emetic in case of poisoning as a first-aid treatment. Sodium Chloride is used to reduce swelling of the cornea in certain eye conditions. Sodium Chloride is used orally to prevent heat cramps due to the depletion of it, also used in addison's dosease.

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Primary Characteristics

It is of Natural origin and belongs to Salt.

It belongs to Minerals and Electrolytes pharmacological group on the basis of mechanism of action and also classified in Abortifacients pharmacological group.

Molecular Weight: 58.5 · pK_a: not relevant · Solubility in Water: 1 in 3 · Solubility in Alcohol: slight · Non-proprietary name: Sodium Chloride · pH: 6.7 · Isotonic value: 0.9.

Pharmacokinetics

None recorded.

Indications

Sodium Chloride is primarily indicated in conditions like Dehydration, Electrolyte disorder, Hyponatraemia, Leg cramps, Sodium depletion.

Sodium Chloride is also indicated for secondary conditions like Diabetic ketoacidosis, Poisoning.

Contraindications

Sodium Chloride is contraindicated in conditions like Hypertension, Ischaemic heart disease, Liver cirrhosis, Nephrotic syndrome, Congestive heart failure.

Dosage

Sodium Chloride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.9 %	0.9 %	—	IV Inf	500-1000 ml, as required.
2.5 lit	2.5 lit	—	IV Inf	May be given over 2-3 hours.Thereafter infusion can usually be at a slower rate.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Sodium Chloride are Vomiting, Diarrhea, Hemorrhage , Nausea, Disseminated intravascular coagulopathy.

Sodium Chloride is known to cause more or less tolerable side effects which are usually transient. These include Fluid overload, Hypernatremia, Thrombophlebitis .

Warnings / Precautions

Sodium chloride should be used with caution in the presence of CHF (congestive heart failure), circulatory insufficiency, kidney dysfunction, hypertension, peripheral edema or hypoproteinemia. When sodium supplements are administered by mouth, adequate water intake should be maintained. Sustained release tablets should not be administered to patients with gastrointestinal disorders, because of the risk of obstruction.

Interference in Pathology

Sodium Chloride may interfere in the diagnosis of Monitoring of electrolyte concentrations.

Available Brands

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Single Ingredient

Drops

Eye Drops

Inf

Inf

Inj

Nasal Drops

Multi-Ingredient Combinations

Storage Conditions

Sodium Chloride should be stored Eye Drops, Eye Oint.

Drug Classification

1.25.4 — Nasal preparations
2.26.2.1 — Electrolytes (NaCl, KCl & Bicarbonate) and combinations

Manufacturers

Manufacturers of Sodium Chloride in Pakistan: