Sodium Nitrite
Sodium Nitrite used in conjuction with sodium thiosulphate in the treatment of cyanide poisoning. It forms cyanomethhaemoglobin which does not demage the cell respiration and eventually converted into less toxic thiocyanate by the thiosulphate.
Primary Characteristics
It is of Synthetic origin and belongs to Sodium Salt.
It is classified in Antidotes pharmacological group.
Molecular Weight: 69 · Solubility in Water: 1 in 1.5 · Solubility in Alcohol: 1 in 160 · Non-proprietary name: Sodium nitrite · pH: 8.5 · Isotonic value: 1.08.
Pharmacokinetics
Elimination: renal excretion is 40 %.
Advertisement
Indications
Sodium Nitrite is primarily indicated in conditions like Cyanide poisoning, Poisoning.
Contraindications
Sodium Nitrite is contraindicated in conditions like Methaemoglobinaemia, Haemolytic anaemia, G6pd deficiency.
Dosage
Sodium Nitrite's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4.29 mg/kg | 4.29 mg/kg | — | IV | Every 1/2 hour till required |
| 0.21 mg/kg.min | 0.21 mg/kg.min | — | IV Inf | For 20 Minutes, As Required |
| Paediatric Dosage (20kg) | ||||
| 3.33 mg/kg.min | 3.33 mg/kg.min | — | IV Infusion | For 3 Min or As Required |
| Neonatal Dosage (3kg) | ||||
| 3.33 mg/kg.min | 3.33 mg/kg.min | — | IV Infusion | For 3 Min or As Required |
Drug Interactions
None recorded.
Side Effects
Sodium Nitrite produces potentially life-threatening effects which include Hypotension, Methemoglobinemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Sodium Nitrite are Poisoning .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.4.2.7 — Cyanide poisoning