Silver Nitrate
Silver Nitrate is antiseptic, disinfectant, astringent and a caustic agent. Silver ion, as an antiseptic has a very broad spectrumespecially against those organism that commonly invade burn wounds, therefore silver nitrate is successfully in the management of severe burns.
Primary Characteristics
It is of Natural origin and belongs to Silver Salt.
It belongs to Dermatological-Caustic pharmacological group on the basis of mechanism of action. It is also classified under Dermatological Products .
Molecular Weight: 169.9 · Solubility in Water: 1 in 0.4 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Silver Nitrate · pH: 5 · Isotonic value: 2.74.
Pharmacokinetics
Absorption: Silver Nitrate has an oral bioavailability is 45.5% (±4.5%).
Distribution: Silver Nitrate has a plasma protein binding is high.
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Indications
Silver Nitrate is primarily indicated in conditions like Bladder hemorrhage, Burn wounds, Eczema, Epidermal necrolysis, Haematuria, Hematuria, Interstitial cystitis, Nasal epistaxis, Ophthalmia neonatorum, Ophthalmia neonatorum, Pneumothorax, Rhinitis, Warts.
Silver Nitrate is also indicated for secondary conditions like Aphthous and herpetic ulcers.
Contraindications
Silver Nitrate is contraindicated in conditions like Wounds, Broken skin, Cuts, Hypersensitivity to any component of product.
Dosage
Silver Nitrate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.5 % | 0.5 % | — | Topical | As Required |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| 1 % | 1 % | — | Topical | As required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Silver Nitrate produces potentially life-threatening effects which include Electrolyte and volume depletion, Methemoglobinemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Silver Nitrate are Vomiting, Convulsions , Sialorrhea, Shock, Hemorrhagic gastroenteritis, Coma, Local trauma, Cataracts , Metallic taste, Pain in mouth, Diarrhea, Corneal opacification.
Silver Nitrate is known to cause more or less tolerable side effects which are usually transient. These include Conjunctivitis.
Warnings / Precautions
Interference in Pathology
Silver Nitrate may interfere in the diagnosis of Protein-bound iodine estimation of Thyroid Function .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.15 — Disinfectants and antiseptics
- 2.21.7 — Other ophthalmologicals