Silver Sulphadiazine
Silver Sulphadiazine is a topical anti-infective agent with the antibacterial properties of both silver ion and sulfadiazine. Both free silver and the sulfonamide moiety may exert activity, Silver Sulphadiazine is used to prevent and treat infections of wounds caused by second- and third-degree burns. The drug does not inhibit folic acid synthesis as other sulfonamides do, rather disrupts bacteria by damaging the cell membrane and the cell wall. It has a wide spectrum of bactericidal activity against both gram-positive and gram-negative organisms.
Primary Characteristics
It is of Synthetic origin and belongs to Sulphonamide.
It belongs to Antibiotics, Other pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Topical pharmacological group.
Molecular Weight: 357.1 · Solubility in Water: < 1 in 10000 · Non-proprietary name: Silver Sulphadiazine.
Pharmacokinetics
Absorption: Silver Sulphadiazine has an oral bioavailability is 7.5% (±2.5%).
Distribution: Silver Sulphadiazine has a volume of distribution is 0.36 l/kg. plasma protein binding is 29 - 45 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 10 - 12 hr.
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Indications
Silver Sulphadiazine is primarily indicated in conditions like Bacterial infections, Burns and scalds, Infections, Wounds.
Contraindications
Silver Sulphadiazine is contraindicated in conditions like Pregnancy, Hypersensitivity to any component of product.
Dosage
Silver Sulphadiazine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 % | 1 % | — | Topical | As Required |
| Paediatric Dosage (20kg) | ||||
| 1 % | 1 % | — | Topical | As Required . For above 3 yrs of children |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Silver Sulphadiazine in overdosage may give rise to further complications which include Nephrotic syndrome , Glomerulonephritis , Leucopenia.
Silver Sulphadiazine is known to cause more or less tolerable side effects which are usually transient. These include Skin rashes.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.13.2.1 — Antibacterials, topical