Sennosides

Also known as: Senna

Drug #656

Sennosides is a natural complex of anthraquinone glycosides found in senna, isolated from Cassia angustifolia. Sennosides is a laxative. Sennosides is used in constipation, causes the evacuation of bowel and also used to clear the intestine before rectal or bowel examinations.

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Primary Characteristics

Sennosides is also known as Senna.

It is of Natural origin and belongs to Glycoside.

It belongs to Laxatives pharmacological group on the basis of mechanism of action and also classified in Stimulant pharmacological group.

Molecular Weight: 862.7 · Solubility in Water: Insoluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Sennosides.

Pharmacokinetics

Elimination: it is metabolised via Gut Lumen, renal excretion is < 5 %.

Indications

Sennosides is primarily indicated in conditions like Constipation.

Contraindications

Sennosides is contraindicated in conditions like Intestinal obstruction, Acute or chronic abdominal symptoms.

Dosage

Sennosides's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 24h	PO	For 3 Days
Paediatric Dosage (20kg)
0.563 mg/kg	0.563 mg/kg	Every 24h	Oral	At Bed Time
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Sennosides in overdosage may give rise to further complications which include Cathartic colon , Muscularis mucosae hypertrophies , Schwann cell proliferation , Dilated aperistaltic colon , GI smooth muscle atrophy, Submucosal depletion of adipose tissue , Pseudo strictures , Loss of colonic haustral pattern .

The signs and symptoms that are produced after acute overdosage of Sennosides are Dehydration.

Sennosides is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Abdominal discomfort, Diarrhea, Nausea.

Warnings / Precautions

Sennoside should be used with caution in patients with kidney disease, heart disease, high blood pressure, oedema or allergy, especially to tartrazine.

Available Brands

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Single Ingredient

Tabs

7.5 mg

Storage Conditions

Sennosides should be stored Tab, Syrup.

Drug Classification

1.17.6 — Laxatives

Manufacturers

Manufacturers of Sennosides in Pakistan:

Reckitt