DrugInfoSys

Retinol (Vitamin A)

Also known as: Antixeropthalmic Vitamin, Vitamin A, Vitamin A palmitate

Drug #646

Retinol (Vitamin A) is a fat soluble vitamin and it was the first fat soluble vitamin discovered. Vitamin A is essential for normal visual function, for healthy skin and for growth. May consist retinol or its esters, formed from edible fatty acids, principally acetic acid and palmitic acid. The major source of viatmin A is yellow and green leafy vegetable and yellow fruits, egg yolk, liver, kidney and fish. Retinol (Vitamin A) is included in many multivitamin preparations.

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Primary Characteristics

Retinol (Vitamin A) is also known as Antixeropthalmic Vitamin, Vitamin A, Vitamin A palmitate.

It is of Synthetic origin and belongs to Cyclohexane Nonatetraene.

It is classified in Vitamin, Fat Soluble pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 286.46 · Solubility in Water: Insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Retinol (Vitamin A).

Molecular structure of Retinol (Vitamin A)

Pharmacokinetics

Absorption: Retinol (Vitamin A) has an oral bioavailability is 22.5% (±22.5%).

Elimination: it is metabolised via Hepatic And Peripheral Tissues, plasma half-life is 2weeks.

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Indications

Retinol (Vitamin A) is primarily indicated in conditions like Adjunctive therapy without valproate, Bronchitis, Pneumonia, Rsv infection, Skin diseases, To reduce degradation of pancreatic enzyme supplements, Vitamin deficiency.

Retinol (Vitamin A) is also indicated for secondary conditions like Biliary cirrhosis, Cholestasis, Measles, Xerophthalmia.

Contraindications

Retinol (Vitamin A) is contraindicated in conditions like Hypervitaminosis, Hypersensitivity.

Dosage

Retinol (Vitamin A)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
257500 mg257500 mgEvery 24hPOAs required
Paediatric Dosage (20kg)
20000 IU/kg20000 IU/kg—Oral For Once
Neonatal Dosage (3kg)
12500 IU/kg12500 IU/kg—OralSingle dose. Not recommended under 6 months of child

Drug Interactions

Unknown11 interactions
2 interactions
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Retinol (Vitamin A) in overdosage may give rise to further complications which include Peeling & redness of skin , Hair loss , Anorexia .

Retinol (Vitamin A) produces potentially life-threatening effects which include intracranial pressure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Retinol (Vitamin A) are redness o f skin.

Retinol (Vitamin A) is known to cause more or less tolerable side effects which are usually transient. These include Dry skin, Headache, Hypercalcemia, Hypersensitivity , Hypervitaminosis , Irritability, Nausea, Skin cracking, Transient hydrocephalus, Vomiting , Weight loss.

Warnings / Precautions

Supervise prolonged daily administration over 25000 IU. Evaluate Vit.A intake from diet, fortified food & drugs. Excessive dose of vitamin A should be avoided during pregnancy. Use with caution in patients with renal impairments, renal dialysis

Available Brands

Storage Conditions

Retinol (Vitamin A) should be stored Inj. Tab.

Drug Classification

  1. 1.21.7 — Other ophthalmologicals
  2. 2.27 — Vitamins, minerals, tonics, and other susbstances

Manufacturers