Rauwolfia Reserpine
Rauwolfia Reserpine is antihypertensive drug. Rauwolfia Reserpine is given in the treatment of high blood pressure and also used as an antipsychotic agent.
Primary Characteristics
It is of Natural origin and belongs to Alkaloid.
It belongs to Amine depletion pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 608.7 · pKa: 6.6 · Solubility in Water: Insoluble · Solubility in Alcohol: 1 in 1800 · Non-proprietary name: Rauwolfia Reserpine.
Pharmacokinetics
Absorption: Rauwolfia Reserpine has an oral bioavailability is 30%.
Distribution: Rauwolfia Reserpine has a plasma protein binding is 96 %.
Elimination: plasma half-life is 1- 2 weeks.
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Indications
Rauwolfia Reserpine is primarily indicated in conditions like Agitation, Cerebrovascular accident, Hypertension, Hypertension in pregnancy, Hypertensive emergencies, Psychosis.
Rauwolfia Reserpine is also indicated for secondary conditions like Peripheral vasospasm.
Contraindications
Rauwolfia Reserpine is contraindicated in conditions like Asthma, Depression, Peptic ulcer, Renal failure, Bronchitis.
Dosage
Rauwolfia Reserpine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.07 ug/kg | 1.07 ug/kg | Every 24h | PO | Maintenance |
| 3.57 ug/kg | 3.57 ug/kg | Every 24h | PO | Initial |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not indicated in children | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Rauwolfia Reserpine in overdosage may give rise to further complications which include Bronchospasm , Congestive heart failure , Dyskinesias , Dystonia , Parkinsonism .
Rauwolfia Reserpine produces potentially life-threatening effects which include Depression of CNS, Angioimmunoblastic lymphadenopathy. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Rauwolfia Reserpine are Bradycardia, Bronchospasm, Coma, Unconsciousness, Respiratory depression, Hypothermia, Tremor, Dystonic movements.
Rauwolfia Reserpine is known to cause more or less tolerable side effects which are usually transient. These include Amenorrhea, Drowsiness, Fluid retention, Galactorrhea, Impotence, Increased appetite, Increased intracranial pressure, Loose stools, Loss of libido, Menstrual irregularity, Nasal congestion , Nightmares, Ocular palsies, Restlessness, Sleep disturbance, Weight gain.
Warnings / Precautions
Interference in Pathology
Rauwolfia Reserpine may interfere in the diagnosis of Estimation of urinary Corticosteroids,17-hydroxycorticosteroids by Porter-Silber reaction. , Estimation of 17-ketosteroids by interference with Zimmerman Reaction .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.8 — Ganglion blocking drugs
- 2.24.1 — Drugs used in psychotic disorders