Protriptyline (HCl)

Drug #632

Protriptyline (HCl) is a tricyclic antidepressant, closely related to imipramine. Protriptyline (HCl) is used to treat depression associated with withdrawal and lack of energy.

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Primary Characteristics

It is of Synthetic origin and belongs to Tricyclic Propylamine.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 299.8 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 3.5 · Non-proprietary name: Protriptyline (HCl).

Molecular structure of Protriptyline (HCl)

Pharmacokinetics

Absorption: Protriptyline (HCl) has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Protriptyline (HCl) has a volume of distribution is 15 - 31.2 l/kg. plasma protein binding is 91 - 93 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 54 - 124 hr, renal excretion is extensive.

Indications

Protriptyline (HCl) is primarily indicated in conditions like Depression.

Contraindications

Protriptyline (HCl) is contraindicated in conditions like Cardiac arrhythmia, Myocardial infarction, Heart block.

Dosage

Protriptyline (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.13 mg/kg	0.13 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown9 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Protriptyline (HCl) in overdosage may give rise to further complications which include Ataxia , Nightmares , Fatigue , Peripheral neuropathy , Extrapyramidal symptoms, Dizziness , Disorientation , Confusion , Drowsiness , Numbness , Paresthesia.

Protriptyline (HCl) produces potentially life-threatening effects which include Mania , Worsening of psychosis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Protriptyline (HCl) are Drowsiness, Fever, Tachycardia , Stupor , Coma.

Protriptyline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Dry mouth, Hyperhidrosis , Mydriasis, Urinary retensionX.

Warnings / Precautions

Protriptyline should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures, sunscreens e.t.c.against exposure to UV light or sun light.

Interference in Pathology

Protriptyline (HCl) may interfere in the diagnosis of None well documented.

Available Brands

None recorded.

Storage Conditions

Protriptyline (HCl) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression