Prothionamide

Drug #631

Prothionamide used in the treatment of tuberculous (T.B.). The actions, uses similar to ethionamide.

Primary Characteristics

It is of Synthetic origin and belongs to Pyridine.

It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action. It is also classified under Antituberculous Drugs .

Molecular Weight: 180.29 · Solubility in Water: soluble · Solubility in Alcohol: soluble · Non-proprietary name: Prothionamide.

Pharmacokinetics

Absorption: Prothionamide has an oral bioavailability is 92.5% (±2.5%).

Elimination: it is metabolised via Hepatic, plasma half-life is 1.5 - 2.1 hr, renal excretion is extensive.

Indications

Prothionamide is primarily indicated in conditions like Leprosy, Tuberculosis.

Contraindications

Prothionamide is contraindicated in conditions like Hepatic disease, General dose, Chronic resistant vaginal candidiasis.

Dosage

Prothionamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4.46 mg/kg	4.46 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Dose not established for children
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Prothionamide in overdosage may give rise to further complications which include Hepatitis , Liver damage , GI dysfunction.

Prothionamide produces potentially life-threatening effects which include Convulsions , Hepatitis . Careful monitoring is needed with proper medical management.

Prothionamide is known to cause more or less tolerable side effects which are usually transient. These include Depression, Headache, Insomnia, Paresthesias, Sleepiness.

Warnings / Precautions

Prothionamide should not be given to patients with severe liver disease. It is suggested that Prothionamide should be avoided during pregnancy or in women of child bearing potentials unless the benefits outweigh its possible hazards.

Interference in Pathology

Prothionamide may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Storage Conditions

Prothionamide should be stored Tab, Inj.

Drug Classification

1.6.2.4 — Anti-tuberculosis drugs