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Pseudoephedrine (HCl)

Drug #633

Pseudoephedrine (HCl) is a sympathomimetic agent, closely related to ephedrine. Pseudoephedrine (HCl) is used in various cough and cold preparations as a nasal decongestant, provides relief from the nasal or sinus congestion.

Primary Characteristics

Pseudoephedrine (HCl) is also known as Pseudoephedrine, Pseudoephedrine Sulphate.

It is of Natural origin and belongs to Alkaloid.

It belongs to Alpha & Beta adrenergic agonist pharmacological group on the basis of mechanism of action. It is also classified under Nasal Decongestants .

Molecular Weight: 201.7 · pKa: 9.22 · Solubility in Water: 1 in 1.6 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Pseudoephedrine (HCl).

Molecular structure of Pseudoephedrine (HCl)

Pharmacokinetics

Absorption: Pseudoephedrine (HCl) has an oral bioavailability is 96.5% (±1.5%).

Distribution: Pseudoephedrine (HCl) has a volume of distribution is 2-3 l/kg.

Elimination: it is metabolised via Hepatic, plasma half-life is 5.4-8 hr, renal excretion is > 90%.

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Indications

Pseudoephedrine (HCl) is primarily indicated in conditions like Bronchospasm, Nasal congestion, Rhinitis, Upper respiratory tract infections.

Contraindications

Pseudoephedrine (HCl) is contraindicated in conditions like Diabetes mellitus, Hypertension, Hyperthyroidism, Prostatic hypertrophy, Cardiovascular disease, Endocrine disorder.

Dosage

Pseudoephedrine (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
60 – 240 mgEvery 4hPO
120 mg120 mgEvery 2hPO
Paediatric Dosage (20kg)
1.5 mg/kg1.5 mg/kgEvery 8hOral -
Neonatal Dosage (3kg)
1.25 mg/kg1.25 mg/kgEvery 8hOral

Drug Interactions

Unknown8 interactions
6 interactions
Major1 interaction
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pseudoephedrine (HCl) produces potentially life-threatening effects which include Hypertension, Unconsciousness. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Pseudoephedrine (HCl) are Hyperreflexia , Hypertonicity , Rapid Speech , Tachycardia , Restlessness , Excitation , Pupillary dilatation, Hallucinations .

Pseudoephedrine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Anxiety, Drowsiness, Dry mouth, Insomnia, Restlessness, Sleep disturbancesX, Tremor.

Warnings / Precautions

Although pseudoephedrine has no significant pressure effect in normotensive patients, It should be used with caution in the patient with hypertension, patients using tricyclic antidepressants, decongestant, appetite suppressants and amphetamine like psychostimulants. Particular care should also be taken in treating patient with underlyning diseases associated with autonomic dysfunction, such as long standing insulin-dependent diabetes mellitus or thyroid disease. Other conditions also exacerbated by pseudoephedrine include myocardial ischmia, cardiac arrhythmia, glucoma, and urinary retension. Do not take the drug more than seven days. Use with great caution in the presence of liver or the kidney impairment. Use topical decongestant (pseudoephedrine) only in acute conditions, not longer than 3 to 5 days. It should be used sparingly in all patients, especially in infants, children and in cardiac patients. Patient should not derive or operate machinery until they have determined their own response. Concomitant use of alcohol or other centrally acting sedative should be avoided. not to be used in nursing mother. Not to be used in patient MAOI inhibitors.

Available Brands

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Single Ingredient

Storage Conditions

Pseudoephedrine (HCl) should be stored Syrup. Tab.

Drug Classification

  1. 1.25.2.3Cough sedatives

Manufacturers