Protamine (Sulphate)
Protamine is a heparin antagonst. Protamine (Sulphate) is a purified mixture of simple protein principles extracted from the sperm or testes of suitable species of fish, which has the property of neutralizing heparin. Protamine (Sulphate) is used as an antidote of heparin to inhibit the anticoagulant effect of heparin.
Primary Characteristics
It is of Natural origin and belongs to Protein.
It belongs to Blood Coagulation pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.
Molecular Weight: 4500 · Solubility in Water: sparingly soluble · Solubility in Alcohol: very low · Non-proprietary name: Protamine (Sulphate).
Pharmacokinetics
Elimination: it is metabolised via unknown.
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Indications
Protamine (Sulphate) is primarily indicated in conditions like Heparin overdose.
Contraindications
Protamine (Sulphate) is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Protamine (Sulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.75 mg.min | 3.75 mg.min | — | IV Inf | For 10 Minutes |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 mg/kg.min | — | — | IV Infusion | As per Heparin Dosage |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 mg/kg.min | — | — | IV Infusion | As per Heparin Dosage |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Protamine (Sulphate) produces potentially life-threatening effects which include Anaphylaxis , Catastrophic pulmonary vasoconstriction. Careful monitoring is needed with proper medical management.
Protamine (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Flushing, Hypotension , Urticaria, Warmth feeling.
Warnings / Precautions
Interference in Pathology
Protamine (Sulphate) may interfere in the diagnosis of Fluorescent method of estimating plasma catecholamines .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.4.2.8 — Heparin overdose toxicity