Propylthiouracil

Drug #629

Propylthiouracil used in treatment of hyperthyroidism (overactive thyroid gland). Propylthiouracil decreases the formation of thyroid hormone from thyroid gland.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyrimidine.

It belongs to Thyroid peroxidease inhibitor pharmacological group on the basis of mechanism of action and also classified in Antithyroid pharmacological group.

Molecular Weight: 170.2 · pK_a: 7.5 · Solubility in Water: 1 in 60 · Solubility in Alcohol: 1 in 900 · Non-proprietary name: Propylthiouracil.

Pharmacokinetics

Absorption: Propylthiouracil has an oral bioavailability is 62.5% (±12.5%).

Distribution: Propylthiouracil has a volume of distribution is 30 litre. plasma protein binding is 80 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 1- 3 hr, renal excretion is > 83 %.

Indications

Propylthiouracil is primarily indicated in conditions like Hyperthyroidism, Thyrotoxicosis.

Contraindications

Propylthiouracil is contraindicated in conditions like Hepatitis, Agranulocytosis, Vasculitis.

Dosage

Propylthiouracil's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.71 mg/kg	0.71 mg/kg	Every 8h	PO	Maintenance for 18 Months
2.62 mg/kg	2.62 mg/kg	Every 8h	PO	Load for 4-8 Weeks
Paediatric Dosage (20kg)
1.3 mg/kg	1.3 mg/kg	Every 8h	Oral	Dose for Children 5-12 Yrs Age
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Propylthiouracil produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia , Aplastic Anemia , Hepatitis , Leucopenia , Vasculitis , LE-like syndrome . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Propylthiouracil are Vomiting, Fever, Epigastric pain, Arthralgia, Pruritus , Pancytopenia .

Propylthiouracil is known to cause more or less tolerable side effects which are usually transient. These include Maculopapular rash, Urticaria.

Warnings / Precautions

Excessive dose of antithyroid should not be used, because it may cause hypothyroidism or goiter. Treatment should be discontinued immediately if there is any clinical or lab evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation. Before having an emergency treatment or surgery including dental surgery, tell the doctor about the use of the drug. Propylthiouracil should be use with caution in patients with blood disease.

Interference in Pathology

Propylthiouracil may interfere in the diagnosis of Serum Glucose & Serum Uric Acid by the sequential multiple analyser .

Available Brands

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Single Ingredient

Tabs

50 mg

Storage Conditions

Propylthiouracil should be stored Tab.

Drug Classification

1.18.8 — Thyroid & antithyroid preparations

Manufacturers

Manufacturers of Propylthiouracil in Pakistan:

Pharmedic