Propyliodone

Drug #628

Propyliodone used as radiopque medium for brochographic use. When directly instilled into the bronchi resulting in well-defined bronchograms for atleast 30 min. Because of its toxicity, Propyliodone should only be used if absolutely essential.

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Primary Characteristics

It is of Synthetic origin and belongs to Iodinated Radio-opaque Compounds.

It belongs to Radiopaque Agents pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group.

Molecular Weight: 447 · Solubility in Water: < 1 in 5000 · Solubility in Alcohol: 1 in 500 · Non-proprietary name: Propyliodone.

Pharmacokinetics

Absorption: Propyliodone has an oral bioavailability is 101%.

Elimination: it is metabolised via Lungs and Gut wall.

Indications

Propyliodone is primarily indicated in conditions like Paget's disease of bone, Radiological contrast agent.

Contraindications

Propyliodone is contraindicated in conditions like Asthma, Bronchospasm, Infections, Obstructive airway disease, Heart disease.

Dosage

Propyliodone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg/kg	150 mg/kg	—	Inhalation	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Propyliodone in overdosage may give rise to further complications which include Fever , Bleeding , Dysphagia , Laryngeal perichondritis , Hematoma.

Propyliodone produces potentially life-threatening effects which include Fever , Anaphylaxis , Repiratory obstruction, Cerebral embolization. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Propyliodone are Airway obstruction.

Propyliodone is known to cause more or less tolerable side effects which are usually transient. These include Aching joints, Fever, Headache, Malaise, Nausea and vomiting.

Warnings / Precautions

Propylidone should be used with caution in patients with history of hypersensitivity to iodine. Avoid use in patients with heart disease. It should be used with caution in patients with asthma, pulmonary emphysema. It should be used with extreme caution during pregnancy.

Interference in Pathology

Propyliodone may interfere in the diagnosis of Thyroid Function Test based on iodine measurements , Respiratory Function Test .

Available Brands

None recorded.

Storage Conditions

Propyliodone should be stored Inj.

Drug Classification

1.14.2 — Radiocontrast media