Propantheline (Br)

Drug #625

Propantheline (Br) is antimuscarinic with action, uses and adverse effects similar to those of atropine. Propantheline (Br) is used as an antispasmodic for gastro-intestinal and urinary complaints. Propantheline (Br) is also reduces the secretion of gastric acid and used in peptic ulcer disease.

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Primary Characteristics

It is of Synthetic origin and belongs to Quaternary Ammonium.

It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .

Molecular Weight: 448.5 · Solubility in Water: high · Solubility in Alcohol: high · Non-proprietary name: Propantheline (Br).

Molecular structure of Propantheline (Br)

Pharmacokinetics

Absorption: Propantheline (Br) has an oral bioavailability is 10%.

Elimination: it is metabolised via Small Intestine, renal excretion is > 30 %.

Indications

Propantheline (Br) is primarily indicated in conditions like Adjunctive treatment of partial seizures, Diverticulitis, Duodenal ulcer, GI motality disorder, Hyperhidrosis, Menieres disease, Peptic ulcer, Symptomatic relief of GI-disorders, Urgency and incontinence.

Propantheline (Br) is also indicated for secondary conditions like Enuresis, Pancreatitis, Short bowel syndrome.

Contraindications

Propantheline (Br) is contraindicated in conditions like Cardiac arrhythmia, Glucoma, Reflux oesophagitis, Prostatic hypertrophy.

Dosage

Propantheline (Br)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 8h	PO	1 hour before meal.
Paediatric Dosage (20kg)
0.375 mg/kg	0.375 mg/kg	Every 6h	oral
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

Minor1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Propantheline (Br) in overdosage may give rise to further complications which include Glaucoma , Orthostatic hypotension , Tachycardia , Urinary retention.

Propantheline (Br) produces potentially life-threatening effects which include GI reactions, Cardiac arrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Propantheline (Br) are Respiratory arrest, Neuromuscular blockade.

Propantheline (Br) is known to cause more or less tolerable side effects which are usually transient. These include Impotence.

Warnings / Precautions

Closely monitor patients for therapeutic response and side effects of propantheline. It should not used in high dose because may produce mental depression and mental distrubances. It should be used with caution in patients over 40yr because may increase the risk of glaucoma. It should be used with caution in patients with asthma, heart or renal (kidney) diseases. It should be used with caution in infants and small children.

Available Brands

None recorded.

Storage Conditions

Propantheline (Br) should be stored Tab.

Drug Classification

1.17.5 — Antispasmodics