Propafenone (HCl)
Also known as: Fenopraine HCl
Propafenone (HCl) is antiarrhythmic agent. its spectrum of action is very similar to that of quinidine. its potency as a sodium channel blocker is similar to that of flecainide. It has some structural similarities to propranolol and possess weak ß-adrenergic blocking activity.
Primary Characteristics
Propafenone (HCl) is also known as Fenopraine HCl.
It is of Synthetic origin and belongs to Propiophenone.
It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.
Molecular Weight: 377.9 · pKa: 8.8 · Solubility in Water: low · Solubility in Alcohol: 1 in 100 - 1000 · Non-proprietary name: Propafenone (HCl).
Pharmacokinetics
Absorption: Propafenone (HCl) has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 60% (±30%).
Distribution: Propafenone (HCl) has a volume of distribution is 3.6 l/kg. plasma protein binding is 80 - 90 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 3.6 hr, renal excretion is 18 - 38 %.
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Indications
Propafenone (HCl) is primarily indicated in conditions like Cardiac arrhythmia, Supraventricular tachycardia, Ventricular arrhythmias, Ventricular arrhythmias; Paroxysmal supraventricular tachyarrhythmias.
Contraindications
Propafenone (HCl) is contraindicated in conditions like Cardiogenic shock, Congestive heart failure, Hypotension, Obstructive airway disease.
Dosage
Propafenone (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.21 mg/kg | 3.21 mg/kg | Every 8h | PO | - |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Propafenone (HCl) produces potentially life-threatening effects which include Bradycardia , Hypotension. Careful monitoring is needed with proper medical management.
Propafenone (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Diarrhea, Dizziness, Dry mouth, Headache, Nausea, Taste disturbance, VertigoX, Visual disorders.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.2 — Antiarrhythmic drugs