Progesterone
Also known as: Pregnenedione, Luteal Hormone
Progesterone is a sex hormone, also called as pregnancy hormone. It mainly acts on uterus in sequence with oestrogen, to prepare the endometrium (inner wall of uterus) to receive the fertilized ovum. Progesterone is used in the treatment of abnormal uterine bleeding, breast and uterine cancers, used for contraception and to treat amenorrhea.
Primary Characteristics
Progesterone is also known as Pregnenedione, Luteal Hormone.
It is of Natural origin and belongs to Steroid.
It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 314.5 · pKa: not relevant · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 8 · Non-proprietary name: Progesterone.
Pharmacokinetics
Absorption: Progesterone has an oral bioavailability is 83% (±7%), pre-systemic (first-pass) metabolism accounts for 75%.
Distribution: Progesterone has a volume of distribution is 17 -29 litre. plasma protein binding is 95 - 98 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 3 -6 min, renal excretion is extensive.
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Indications
Progesterone is primarily indicated in conditions like Abortion, Dysfunctional uterine bleeding, Postnatal depression, Premenstrual syndrome, Premenstural syndrome.
Contraindications
Progesterone is contraindicated in conditions like Vaginal bleeding, Cancer, Liver diseases.
Dosage
Progesterone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 62.5 mg | 62.5 mg | Every 24h | IM | |
| 4.29 mg/ kg | 4.29 mg/ kg | Every 24h | Penetration | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Progesterone in overdosage may give rise to further complications which include Amenorrhea, Menstrual irregularities .
The signs and symptoms that are produced after acute overdosage of Progesterone are Uterine cramps, Fainting , Euphoria .
Progesterone is known to cause more or less tolerable side effects which are usually transient. These include Acne, Anal soreness, Diarrhea, Flatulence, Weight gain, Weight loss.
Warnings / Precautions
Interference in Pathology
Progesterone may interfere in the diagnosis of Pregnanediol Test , Metyrapone Test .
Available Brands
Storage Conditions
Drug Classification
- 1.18.5 — Progestogens