Procyclidine (HCl)
Procyclidine (HCl) is antimuscarinic agent. Chemically Procyclidine (HCl) is identified as a-cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride. Procyclidine (HCl) is used mostly as a substitute for trihexyphenidyl in the treatment of parkinson's disease.
Primary Characteristics
It is of Synthetic origin and belongs to Alkaloid.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.
Molecular Weight: 323.9 · pKa: 10.7 · Solubility in Water: 1 in 40 · Solubility in Alcohol: 1 in 15 · Non-proprietary name: Procyclidine (HCl).
Pharmacokinetics
Absorption: Procyclidine (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 25%.
Distribution: Procyclidine (HCl) has a volume of distribution is 1 l/kg. plasma protein binding is moderate.
Elimination: plasma half-life is 12.6 hr.
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Indications
Procyclidine (HCl) is primarily indicated in conditions like Acromegaly, Acute dystonia, Dystonia, Oculogyric crises, Parkinsonism.
Contraindications
Procyclidine (HCl) is contraindicated in conditions like Prostatic hypertrophy, Tardive dyskinesias, Intestinal obstruction, Narrow-angle glaucoma.
Dosage
Procyclidine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2.5 mg | 2.5 mg | Every 8h | PO | Gradually increased to 5mg. |
| 5 mg | 5 mg | Every 24h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| 0.107 mg/kg | 0.107 mg/kg | — | Intra Muscular | Maintenance for once or repeat/20 min As Required |
| 0.25 mg/kg | 0.25 mg/kg | — | Intra Muscular | Load for once, or may be repeated As Required |
| 0.107 mg/kg | 0.107 mg/kg | — | Intra Venous | Maintenance for once or repeat/20 min As Required |
| 0.25 mg/kg | 0.25 mg/kg | — | Slow IV | Load for once, or may be repeated As Required |
| Neonatal Dosage (3kg) | ||||
| 0.312 mg/kg | 0.312 mg/kg | — | Intramuscular | Single dose |
| 0.312 mg/kg | 0.312 mg/kg | — | Intravenous | Single dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Procyclidine (HCl) in overdosage may give rise to further complications which include Dizziness , Visual hallucination , Excitement .
Procyclidine (HCl) produces potentially life-threatening effects which include Confusion . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Procyclidine (HCl) are Visual hallucination, Dry mouth, Restlessness , Agitation, Constipation, Urinary retention, Confusion , Blurred vision.
Procyclidine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Blurred vision, Confusion, Constipation , Dry mouth, Restlessness, Urinary retensionX.
Warnings / Precautions
Interference in Pathology
Procyclidine (HCl) may interfere in the diagnosis of None well documented.
Available Brands
Storage Conditions
Drug Classification
- 1.9.1 — Drugs used in parkinsonism