Proguanil (HCl)

Also known as: , Proguanide HCl, Chloroguanide HCl

Drug #619

Proguanil (HCl) is antimalarial agent. Proguanil (HCl) is a dihydrofolate reductase inhibitor. Proguanil (HCl) is a biguanide derivative.

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Primary Characteristics

Proguanil (HCl) is also known as , Proguanide HCl, Chloroguanide HCl.

It is of Synthetic origin and belongs to Biguanide.

It belongs to Dihydrofolate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.

Molecular Weight: 290.2 · pK_a: 2.3, 10.4 · Solubility in Water: 1 in 110 · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Proguanil (HCl).

Pharmacokinetics

Absorption: Proguanil (HCl) has an oral bioavailability is 92.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Distribution: Proguanil (HCl) has a plasma protein binding is 75 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 11.8 - 23.4 hr, renal excretion is > 60 %.

Indications

Proguanil (HCl) is primarily indicated in conditions like Duodenal ulcer associated with h. Pylori, Malaria, Malaria prophylaxis.

Contraindications

Proguanil (HCl) is contraindicated in conditions like Renal failure, Renal diseases.

Dosage

Proguanil (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.5 mg/kg	1.5 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
5 mg/kg	5 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
3.125 mg/kg	3.125 mg/kg	Every 24h	Oral

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Proguanil (HCl) are Abdominal pain, Vomiting, Hematuria, Diarrhea.

Proguanil (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Epigastric discomfort, Mouth ulcers, Skin reactions, Stomatitis.

Warnings / Precautions

Proguanil should be used with caution in people with impaired kidney function. Pregnant women should take folic acid supplements.

Available Brands

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Multi-Ingredient Combinations

Tabs

100 mg 25 mg

Storage Conditions

Proguanil (HCl) should be stored Tab.

Drug Classification

1.6.4.3 — Antimalarials

Manufacturers

Manufacturers of Proguanil (HCl) in Pakistan:

Hilton