Procaine Penicillin
Also known as: Benzyl Penicillin Novocain, Penicillin G Procain
Procaine Penicillin is a long acting penicillin similar to benzylpenicillin, used to treat a large variety of bacterial infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Procaine Penicillin is important to take the drug for the full time period as prescribed. If you discontinue the therapy may result in ineffective treatment.
Primary Characteristics
Procaine Penicillin is also known as Benzyl Penicillin Novocain, Penicillin G Procain.
It is of Natural origin and belongs to Aminobenzoate.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.
Molecular Weight: 588.7 · Solubility in Water: 1 in 200 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Procaine Penicillin.
Pharmacokinetics
Distribution: Procaine Penicillin has a plasma protein binding is 60 %.
Elimination: it is metabolised via < 30 % Hepatic, plasma half-life is 0.5 hr.
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Indications
Procaine Penicillin is primarily indicated in conditions like Bacterial infections, Gonorrhoea, Syphilis.
Procaine Penicillin is also indicated for secondary conditions like Endocarditis, Pneumonia.
Contraindications
Procaine Penicillin is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Procaine Penicillin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4 MIU | 4 MIU | — | IM | |
| Paediatric Dosage (20kg) | ||||
| 10 mg/kg | 10 mg/kg | Every 24h | Intra Muscular | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Procaine Penicillin in overdosage may give rise to further complications which include Hemolytic anemia , Jarisch herxheimer reaction , Renal impairment , Serum sickness .
Procaine Penicillin produces potentially life-threatening effects which include Convulsions , Hypotension, Hematological abnormalities, Renal damage, Cardiopulmonary arrest, Anaphylaxis . Careful monitoring is needed with proper medical management.
Procaine Penicillin is known to cause more or less tolerable side effects which are usually transient. These include Abscess, Anxiety, Contact dermatitis, Hypertension , Pain , Skin rashes, Tachycardia.
Warnings / Precautions
Interference in Pathology
Procaine Penicillin may interfere in the diagnosis of Flase +ve values of 17-OH-Corticosteroids, 17-Ketosteroids, 17-Ketogenic Steroids , It may interferes with Thyroid Function Test .
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.1 — Penicillins