Probucol
Probucol is an antihyperlipidimic agent, used in the treatment of primary hypercholesterolemia. Chemically Probucol is identified as acetone bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole, a substituted bis-phenol structurally unrelated to other currently available antihyperlipidemic agents. It exerts its lipid-lowering action mainly on cholesterol, with relatively little effect on triglycerides. It inhibits the transport of cholesterol from the intestine and may interfere with the conversion of acetate to mevalonic acid, an early stage in cholesterol synthesis, but does not affect the later stages of cholesterol synthesis. It may also increase the fecal excretion of cholesterol and bile acids via the bile. it was approved by the FDA in 1977.
Primary Characteristics
It is of Synthetic origin and belongs to Phenols.
It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.
Molecular Weight: 516.9 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Probucol.
Pharmacokinetics
None recorded.
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Indications
Probucol is primarily indicated in conditions like Hypercholesterolaemia.
Contraindications
Probucol is contraindicated in conditions like Cardiac arrhythmia, Diarrhoea.
Dosage
Probucol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7.14 mg/kg | 7.14 mg/kg | Every 12h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Safety not established | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Probucol produces potentially life-threatening effects which include Torsades de pointes. Careful monitoring is needed with proper medical management.
Probucol is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea.
Warnings / Precautions
Interference in Pathology
Probucol may interfere in the diagnosis of Elevations of SGPT and SGOT , Increased Alkaline Phosphatase Levels, Elevation in ALT or AST, Increased level of Blood urea nitrogen (BUN) concentrations, Increased blood glucose level, Increases serum uric acid, Increased concentration of creatinine kinase.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.6 — Lipid-regulating drugs /Anti-atheromas