Probenecid - Drug Monograph | DrugInfoSys ODIS

Primary Characteristics

It is of Semi Synthetic origin and belongs to Benzoic Acid.

It belongs to Renal tubular anion resorption inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 285.4 · pK_a: 3.4 · Solubility in Water: almost Insoluble · Solubility in Alcohol: 1 in 25 · Non-proprietary name: Probenecid.

Pharmacokinetics

Absorption: Probenecid has an oral bioavailability is 100%.

Distribution: Probenecid has a volume of distribution is 11 litre. plasma protein binding is 90 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 4 - 17 hr, renal excretion is 90%.

Indications

Probenecid is primarily indicated in conditions like Galactorrhoea, Gout, Hypogonadism, Infertility, Infertility without hyperprolactinaemia.

Probenecid is also indicated for secondary conditions like Infections, Prostate cancer, flare with initial gonadorelin therapy.

Contraindications

Probenecid is contraindicated in conditions like Peptic ulcer, Renal failure, Blood dyscrasias, Acute gout attack, Kidney stone.

Dosage

Probenecid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 mg	250 mg	Every 2h	PO	Initially for Several Weeks
1250 mg	1250 mg	Every 2h	PO	Maintenance 2gm will be given in 4 divided doses.
Paediatric Dosage (20kg)
10 mg/kg	10 mg/kg	Every 6h	Oral	Maintenance, As Required
25 mg/kg	25 mg/kg	—	Oral	Initially Once (Rec for Paeds over 2 Yrs)
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown58 interactions

22 interactions

Major1 interaction

Minor5 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Probenecid produces potentially life-threatening effects which include Aplastic Anemia , Hemolytic anemia, Leucopenia , Hepatic necrosis, Anaphylactic reactions. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Probenecid are Convulsions , Stupor , CNS stimulation, Vomiting, Coma, Tonic-clonic seizures.

Probenecid is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Anorexia , Dermatitis, Dizziness, Fever, Flushing, Headache, Nausea, Nephrolithiasis , Nephrotic syndrome, Pruritus , Rashes , Sore gums, Stevens Johnson syndrome, Urinary frequency, Urticaria, Vomiting .

Warnings / Precautions

Probencid should be used with caution in patients with history of peptic ulcer, acute intermittent porphyria and glucose 6 phosphate dehydrogenase (G-6-PD) deficiency. Dosage requirement may be increase in renal impairment. Adequate fluid intake is required (2 to 3 litres) During first few months of treatment, sodium bi carbonate may be given to render Urine Alkaline

Interference in Pathology

Probenecid may interfere in the diagnosis of Glucose Test .

Available Brands

None recorded.

Storage Conditions

Probenecid should be stored Tab.

Drug Classification

1.2.3 — Antigout preparations