Poldine (Methylsulphate)
Poldine (Methylsulphate) reduces acid secretion of stomach and is used in the treatment of peptic ulcer.
Primary Characteristics
It is of Synthetic origin and belongs to Pyrole.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 451.5 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 20 · Non-proprietary name: Poldine (Methylsulphate).
Pharmacokinetics
Elimination: renal excretion is 11 %.
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Indications
Poldine (Methylsulphate) is primarily indicated in conditions like Cataplexy, Depression, Obsessive-compulsive disorders, Peptic ulcer, Phobic states.
Poldine (Methylsulphate) is also indicated for secondary conditions like Acne, Endocrine adenomas, Hyperhidrosis, Zollinger-ellison syndrome.
Contraindications
Poldine (Methylsulphate) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Heart block, Narrow-angle glaucoma, Hypersensitivity, Urinary retention.
Dosage
Poldine (Methylsulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.442 mg/kg | 0.442 mg/kg | Every 24h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0.2 mg/kg | 0.2 mg/kg | Every 24h | Oral | At bed time |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not used in this age group | |
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Poldine (Methylsulphate) are Tachycardia , Hallucinations , Delirium, Tachypnea, Confusion , Hyperpyrexia, Excitation .
Poldine (Methylsulphate) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Dry mouth, Tachycardia, Urinary hesitancy.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics