Podophyllum
Podophyllum is used as a caustic for removal of warts, calluses and papillomas etc. It was formerly used as a cathartic.
Primary Characteristics
It is of Natural origin and belongs to Alkaloid.
It belongs to Dermatological-Caustic pharmacological group on the basis of mechanism of action. It is also classified under Dermatological Products .
Molecular Weight: 414.4 · Solubility in Water: slightly soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Podophyllum.
Pharmacokinetics
None recorded.
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Indications
Podophyllum is primarily indicated in conditions like Warts.
Contraindications
Podophyllum is contraindicated in conditions like Haemorrhage, Friable warts.
Dosage
Podophyllum's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.225 % | 0.225 % | — | Topical | As Required |
| Paediatric Dosage (20kg) | ||||
| 22.5 % | 22.5 % | — | Topical | As Required |
| Neonatal Dosage (3kg) | ||||
| 22.5 % | 22.5 % | — | Topical | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Podophyllum in overdosage may give rise to further complications which include Diarrhoea , Paralytic ileus , Coma , Confusion , Delirium , Leucopenia, Abdominal pain, Lethargy , Neuropathy , Vomiting .
The signs and symptoms that are produced after acute overdosage of Podophyllum are Diarrhea, Abdominal pain, Neuropathy , Bone marrow suppression, Nausea & vomiting.
Podophyllum is known to cause more or less tolerable side effects which are usually transient. These include Allergy , Pain , Swelling .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.13.2.2 — Antivirals, topical
- 2.13.5.2 — Others
Manufacturers
Manufacturers of Podophyllum in Pakistan: