Pizotifen (Hydrogen Maleate)
Pizotifen (Hydrogen Maleate) used for the prevention of migraine.
Primary Characteristics
It is of Synthetic origin and belongs to Piperidine.
It belongs to 5HT-2 antagonist pharmacological group on the basis of mechanism of action and also classified in Appetite Stimulant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 429.5 · pKa: 8.7 · Solubility in Alcohol: 1 in 25 · Non-proprietary name: Pizotifen (Hydrogen Maleate).
Pharmacokinetics
Absorption: Pizotifen (Hydrogen Maleate) has an oral bioavailability is 80%.
Distribution: Pizotifen (Hydrogen Maleate) has a volume of distribution is 485. plasma protein binding is 91 %.
Elimination: plasma half-life is 26 hr, renal excretion is 62 %.
Advertisement
Indications
Pizotifen (Hydrogen Maleate) is primarily indicated in conditions like Appetite stimulation, Migraine prophylaxis, Prevention of vascular headache, Prophylaxis of vascular headache.
Contraindications
Pizotifen (Hydrogen Maleate) is contraindicated in conditions like Glucoma, Prostatic hypertrophy.
Dosage
Pizotifen (Hydrogen Maleate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.5 mg | 0.5 mg | Every 8h | PO | Maintenance dose, |
| 0.5 mg | 0.5 mg | — | PO | Initial dose |
| Paediatric Dosage (20kg) | ||||
| 0.02 mg/kg | 0.02 mg/kg | Every 8h | Oral | Dose for Children of 5-12 Yrs |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pizotifen (Hydrogen Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Drowsiness, Dry mouth, Increased appetite.
Warnings / Precautions
Available Brands
Click on a strength to view available brands.
Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.7.2 — Migraine prophylaxis
- 2.27 — Vitamins, minerals, tonics, and other susbstances