Pivmecillinam (HCl)

Drug #582

Pivmecillinam (HCl) is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Pivmecillinam (HCl) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Beta Lactum.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 476 · pK_a: 8.9 · Solubility in Water: 1 in 4 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Pivmecillinam (HCl).

Molecular structure of Pivmecillinam (HCl)

Pharmacokinetics

Absorption: Pivmecillinam (HCl) has an oral bioavailability is 80% (±5%), pre-systemic (first-pass) metabolism accounts for 75%.

Elimination: renal excretion is 60 %.

Indications

Pivmecillinam (HCl) is primarily indicated in conditions like Acute uncomplicated cystitis, Chronic or recurrent bacteriuria, Salmonellosis, UTI.

Contraindications

None recorded.

Dosage

Pivmecillinam (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.857 mg/kg	2.857 mg/kg	Every 8h	PO	Maintenance, upto 8 doses
5.714 mg/kg	5.714 mg/kg	—	PO	Loading
Paediatric Dosage (20kg)
7.5 mg/kg	7.5 mg/kg	Every 6h	Oral	-
Neonatal Dosage (3kg)
7.5 mg/kg	7.5 mg/kg	Every 6h	Oral

Drug Interactions

Unknown1 interaction

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pivmecillinam (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anaphylactoid reactions, Diarrhea, Eosinophilia, Granulocytopenia, Mouth ulcers, Nausea and vomiting, Oesophageal ulcerations, Oesophagitis, Thrombocytopenia.

Warnings / Precautions

During long term use, it is advisable to carry out routine liver and kidney function tests. Pivmecillinam (HCl) should be used with caution in patients with porphyria since pivmecillinam has been associated with acute attacks of porphyria. As with other antibiotics which are excreted mainly by the kidneys, raised blood levels of mecillinam may occur if repeated doses are given to patients with impaired renal function. Pivmecillinam (HCl) should be used with caution for long-term or frequently-repeated treatment, due to the possibility of carnitine depletion.

Interference in Pathology

Pivmecillinam (HCl) may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Storage Conditions

Pivmecillinam (HCl) should be stored Tab, Oral Susp.

Drug Classification

1.6.2.1.1 — Penicillins