Argipressin

Drug #58

Argipressin is a form of vasopressin. Vasopressin is the pressor and antidiuretic principle of posterior lobe of pituitary gland. It may be prepared by synthesis or by extraction from the glands of healthy, domestic animals used for food in man. Vasopressin plays an important role in the long term control of blood pressure through its action on the kidney to increase water reabsorption.

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Primary Characteristics

It is of Synthetic origin and belongs to Polypeptide.

It belongs to Vasopressin V1+V2 agonist pharmacological group on the basis of mechanism of action. It is also classified under Posterior Pituitary Hormones .

Molecular Weight: 1084 · pK_a: 10.9 · Solubility in Water: high · Solubility in Alcohol: low · Non-proprietary name: Argipressin.

Pharmacokinetics

Absorption: Argipressin has an pre-systemic (first-pass) metabolism accounts for 100%.

Distribution: Argipressin has a plasma protein binding is negligible.

Elimination: it is metabolised via via liver & kidney, plasma half-life is 5-15 min, renal excretion is 10-20%.

Indications

Argipressin is primarily indicated in conditions like Bleeding oesophageal varices, Diabetes insipidus.

Contraindications

Argipressin is contraindicated in conditions like Hypertension, Renal diseases, Cardiovascular disease, Primary polydipsia.

Dosage

Argipressin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.006 IU/kg.min	0.006 IU/kg.min	—	IV Inf	For 24-Hours
0.029 IU/kg.min	0.029 IU/kg.min	—	IV Inf	Maintenance, Every 1-2 Hour for Several Days
Paediatric Dosage (20kg)
0.263 IU/kg	0.263 IU/kg	Every 8h	Intra Muscular	Dose for diabetes insipidus
0.263 IU /kg	0.263 IU /kg	Every 8h	Suibcutaneous	Dose foe diabetes insipidus
Neonatal Dosage (3kg)
0.263 IU/kg	0.263 IU/kg	Every 8h	Intra Muscular	Dose for diabetes insipidus
0.263 IU /kg	0.263 IU /kg	Every 8h	Suibcutaneous	Dose foe diabetes insipidus

Drug Interactions

None recorded.

Side Effects

Argipressin produces potentially life-threatening effects which include Myocardial infarction, Myocardial Ischemia , Cardiac dysrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Argipressin are Angina .

Warnings / Precautions

Avoid use argipressin in patients with chronic nephritis with nitrogen retension. Use with caution and in small doses in patients with vascular disease, especially of coronary arteries. It should be given with care to patients with asthma, migrane, epilepsy, heart failure or hypertension. Fluid retention should be adjusted to avoid hyponatraemia.

Available Brands

None recorded.

Storage Conditions

Argipressin should be stored IM Inj, SC Inj, IV Inf.

Drug Classification

1.10.5 — Drugs used in esophageal varices bleeding
2.18.12 — Drugs used in diabetes insipidus