Aprotinin

Drug #57

Aprotinin is an antiplasmin agent i.e. haemostatic. Aprotinin is a serine protease inhibitor. Aprotinin is used in acute pancreatitis (infalmmation of pancrease), in the management of sudden bleeding episodes in haemophilias and other bleeding disorders.

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Primary Characteristics

It is of Natural origin and belongs to Polypeptide.

It belongs to Trypsin inhibitor pharmacological group on the basis of mechanism of action and also classified in Haemorrhage pharmacological group.

Molecular Weight: 6511 · pK_a: strongly basic · Solubility in Water: soluble · Solubility in Alcohol: almost insoluble · Non-proprietary name: Aprotinin.

Pharmacokinetics

Absorption: Aprotinin has an oral bioavailability is 5% (±5%).

Elimination: it is metabolised via renal, plasma half-life is 7 hr, renal excretion is major.

Indications

Aprotinin is primarily indicated in conditions like Abnormal blood loss prevention, Fat embolism syndrome, Hyperfibrionolytic haemorrhage, Hyperplasminaemia, Liver transplantation, Muscle relaxation (short to intermediate duration), Pancreatic and endotoxic shock, Pancreatitis, Ruptured intracranial aneurysm, Traumatic and haemorrhagic shock.

Contraindications

Aprotinin is contraindicated in conditions like Hypersensitivity.

Dosage

Aprotinin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.66 ug/kg.min	1.66 ug/kg.min	—	IV	Maintenance, As Required
2.45 mg/kg	2.45 mg/kg	—	IV	Load for Once
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Aprotinin is known to cause more or less tolerable side effects which are usually transient. These include Hypersensitivity reactions.

Warnings / Precautions

Aprotinin hypersensitivity should be tested prior to administration. All patients should receive a test dose to assess possible allergic reaction. Those who have had previous therapy with aprotinin should be treated with special caution to avoid a possible anaphylactic reaction. In patients being given a repeat dose of aprotinin, an HÀ-histamine antagonist can be administered before the loading dose. Safe use of aprotinin in children has not been established.

Available Brands

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Single Ingredient

Inf

1.4 mg/ml

Storage Conditions

Aprotinin should be stored IV Inj, IV Inf.

Drug Classification

1.10.3 — Antihemorrhagics/Antihemophilics

Manufacturers

Manufacturers of Aprotinin in Pakistan:

Bayer