Piperazine
Piperazine is anthelmintic agent. Piperazine is available as hexahydrate and as a variety of salts such as citrate, phosphate, adipate, tartrate etc. Piperazine is used in the treatment of threadworms and round worms.
Primary Characteristics
It is of Natural origin and belongs to Piperidine.
It is classified in Anthelmintics pharmacological group.
Molecular Weight: 86.14 · pKa: 4.2 · Solubility in Water: 1 in 10 - 30 · Solubility in Alcohol: 1 in 10 - 30 · Non-proprietary name: Piperazine.
Pharmacokinetics
Elimination: renal excretion is 5 - 30 %.
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Indications
Piperazine is primarily indicated in conditions like Helminth infection.
Contraindications
Piperazine is contraindicated in conditions like Epilepsy, Impaired hepatic function, Impaired renal function.
Dosage
Piperazine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4 g | 4 g | Every 24h | PO | For 2 days. |
| Paediatric Dosage (20kg) | ||||
| 100 mg/kg | 100 mg/kg | Every 24h | Oral | Recommended for Ascariasis |
| Neonatal Dosage (3kg) | ||||
| 100 mg/kg | 100 mg/kg | Every 24h | Oral | Recommended for Ascariasis |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Piperazine produces potentially life-threatening effects which include Ataxia, Muscle hypotonia, Somnolence, Impaired conciousness, Clonic convulsions. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Piperazine are Coma, Convulsions .
Piperazine is known to cause more or less tolerable side effects which are usually transient. These include Acute hemolysis, Acute hepatitis, Allergic reactions, GI upset, Purpura, Urticaria.
Warnings / Precautions
Interference in Pathology
Piperazine may interfere in the diagnosis of Estimation of Serum Uric Acid .
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.6.1.1 — Intestinal anthelmintics