Piperacillin (Na)
Piperacillin (Na) is a parenteral, semisynthetic, extended-spectrum acylureidopenicillin. Extended-spectrum penicillins, such as piperacillin, are used mainly in the treatment of serious, gram-negative infections and in combination with an aminoglycoside to treat systemic Pseudomonas infections. Clinically, piperacillin is used to treat intra-abdominal infections, respiratory and urinary tract infections, skin and soft-tissue infections, and other infections caused by susceptible organisms. Piperacillin was approved by the FDA in 1981. its patent expired in September 1995. Piperacillin is a ß-lactam antibiotic and is mainly bactericidal. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall. Penicillin-binding proteins are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell. Penicillin-binding proteins vary among different bacterial species.
Primary Characteristics
Piperacillin (Na) is also known as Piperacillin.
It is of Semi Synthetic origin and belongs to Beta Lactum.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.
Molecular Weight: 539.5 · Solubility in Water: freely Soluble · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Piperacillin (Na).
Pharmacokinetics
Absorption: Piperacillin (Na) has an oral bioavailability is 15.5% (±4.5%).
Distribution: Piperacillin (Na) has a volume of distribution is 16 - 24 l/1.73 meter cube. plasma protein binding is 16 - 22 %.
Elimination: plasma half-life is 36 - 80 min, renal excretion is 80 %.
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Indications
Piperacillin (Na) is primarily indicated in conditions like Bacterial infections, Bone and joint infection, Complicated appendicitis, GI infections, Gonorrhoea, Hodgkin's disease, Meningitis, Respiratory tract infections, Septicaemia, UTI.
Contraindications
None recorded.
Dosage
Piperacillin (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 17500 mg | 17500 mg | — | IV | Daily in div.doses |
| Paediatric Dosage (20kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 6h | Intra Venous | - |
| Neonatal Dosage (3kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 6h | Intravenous | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Piperacillin (Na) in overdosage may give rise to further complications which include Prolongation of bleeding time .
Piperacillin (Na) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
Piperacillin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea, Thrombophlebitis , Vomiting .
Warnings / Precautions
Interference in Pathology
Piperacillin (Na) may interfere in the diagnosis of False +ve Coombs Test .
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.1 — Penicillins