Pinacidil Monohydrate

Drug #575

Pinacidil Monohydrate is potassium channel opener. It is used in the managemnet of hypertension. It produces direct vasodilatation of the arterioles and reduces the blood pressure, and peripheral resistance but causes fluid retension.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyridine.

It belongs to Potassium Channel (ATP sensitive) opener pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.

Molecular Weight: 263.4 · pK_a: 6.0, 10.8 · Solubility in Alcohol: 1 in 7 · Non-proprietary name: Pinacidil Monohydrate.

Molecular structure of Pinacidil Monohydrate

Pharmacokinetics

Absorption: Pinacidil Monohydrate has an oral bioavailability is 73% (±2%).

Distribution: Pinacidil Monohydrate has a volume of distribution is 1.1 - 1.4 l/kg. plasma protein binding is 40 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 1.6 - 2.9 hr, renal excretion is 39 %.

Indications

Pinacidil Monohydrate is primarily indicated in conditions like Bladder hyperactivity, Hypertension, Impotency, Renal hypertension.

Contraindications

Pinacidil Monohydrate is contraindicated in conditions like Cardiac arrhythmia, Ischaemic heart disease, Cerebrovascular disease.

Dosage

Pinacidil Monohydrate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.356 mg/kg	0.356 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not use in children
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pinacidil Monohydrate in overdosage may give rise to further complications which include Palpitation , Oedema , Tachycardia .

Pinacidil Monohydrate is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Headache, Increased intracranial pressure, Nausea, Palpitation, Rashes , Tachycardia.

Warnings / Precautions

Pinacidil monohydrate should be used with caution in patients with symptomatic ischaemic heart disease, cerebrovascular insufficiency, renal or hepatic (liver) dysfunction or pre-existing tachyarrhythmias.

Available Brands

None recorded.

Storage Conditions

Pinacidil Monohydrate should be stored .

Drug Classification

1.12.8 — Other cardiovascular preparations
2.24.6 — Cerebrovascular drugs