Pimozide

Drug #574

Pimozide is a long-acting antipsychotic with general properties similar to that of chlorpromazine. Pimozide is used in psychotic disorder specially in schizophrenia, paranoid states and Tourette`s syndrome. Pimozide is also used to control nausea, vomitting and intractable hiccups.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenylalkylpiperidine.

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 461.54 · pK_a: 8.63 · Solubility in Water: Insoluble · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Pimozide.

Pharmacokinetics

Absorption: Pimozide has an oral bioavailability is 70% (±10%), pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Pimozide has a volume of distribution is 28(10-46)l/kg. plasma protein binding is 99%.

Elimination: it is metabolised via Hepatic, plasma half-life is 53 hr, renal excretion is 60 %.

Indications

Pimozide is primarily indicated in conditions like Delusional disorder, Erotomania, Gille de la tourette syndrome, Mania, Psychosis, Schizophrenia.

Contraindications

Pimozide is contraindicated in conditions like Cardiac arrhythmia, Depression, Parkinsonism, CNS depression, Ecg abnormalities.

Dosage

Pimozide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.128 mg/kg	0.128 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown8 interactions

10 interactions

Major2 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pimozide in overdosage may give rise to further complications which include Tardive dyskinesia .

Pimozide produces potentially life-threatening effects which include Coma, Muscle rigidity, Agranulocytosis, Neuroleptic Malignant Syndrome , Unconsciousness. Careful monitoring is needed with proper medical management.

Pimozide is known to cause more or less tolerable side effects which are usually transient. These include Acute dystonia, Akinesia, Amenorrhea, Anorexia , Extrapyramidal effects, Galactorrhea, Gynecomastia, HyperprolactinemiaX, Insomnia, Oligomenorrhea, Pseudoparkinsonism , Rigidity, Tiredness .

Warnings / Precautions

Patients should be observed caution while driving or performing other tasks requiring alertness, because it may produced drowsiness or blurred vision. Pimozide should be used with caution in patients with kidney or liver diseases. Correct potassium insufficiency and diarrhea before initiating therapy. It should be used with caution in patients whose condition may be aggravated by anticholinergic activity.

Available Brands

None recorded.

Storage Conditions

Pimozide should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders