Antilymphocyte Immune Globulin

Drug #56

Antilymphocyte Immune Globulin may be added in immunosuppressant regimens in organ transplantation patient to treat acute rejection episode, Antilymphocyte Immune Globulin is also used in the treatment of aplastic anemia in patients unsuitable for bone marrow transplantation.

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Primary Characteristics

It is of Natural origin and belongs to Protein.

It belongs to Antibody pharmacological group on the basis of mechanism of action and also classified in Immune Globulin pharmacological group.

Non-proprietary name: Antilymphocyte Immune Globulin.

Molecular structure of Antilymphocyte Immune Globulin

Pharmacokinetics

Distribution: Antilymphocyte Immune Globulin has a volume of distribution is 6.5 litre.

Elimination: plasma half-life is 18-36 hr.

Indications

Antilymphocyte Immune Globulin is primarily indicated in conditions like Aplastic anemia, Bone marrow depletion of t cells, Rejection crises of transplanted organs.

Contraindications

Antilymphocyte Immune Globulin is contraindicated in conditions like Allergy, Thrombocytopenia, Seizures, Parasite infection.

Dosage

Antilymphocyte Immune Globulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.083 mg/kg.min	0.083 mg/kg.min	—	IV Inf	For 4 Hours
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
0 – 0	—	—		Not used in this age group

Drug Interactions

None recorded.

Side Effects

Antilymphocyte Immune Globulin in overdosage may give rise to further complications which include Hypotension , Febrile reactions, Tachycardia .

Antilymphocyte Immune Globulin produces potentially life-threatening effects which include Anaphylactoid reactions , Thrombocytopenia , Serum sickness. Careful monitoring is needed with proper medical management.

Antilymphocyte Immune Globulin is known to cause more or less tolerable side effects which are usually transient. These include Erythema, Local thrombophlebitis, Pruritus .

Warnings / Precautions

Antilymphocyte is not recommended for use during pregnancy or lactation. Immunosuppressant drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, it help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes and should not be inhaled.

Interference in Pathology

Antilymphocyte Immune Globulin may interfere in the diagnosis of False +ve Paul Bunnell Test .

Available Brands

None recorded.

Storage Conditions

Antilymphocyte Immune Globulin should be stored Ampule. Inj (reconstituted soln).

Drug Classification

1.19.2.7 — Antilymphocytic globulin