Phenylpropanolamine (HCl)
Phenylpropanolamine (HCl) is indirectly acting sympathomimitic with prominent peripheral adrenergic effects and weak central stimulant action. Phenylpropanolamine (HCl) is mainly used as a nasal decongestant. Phenylpropanolamine (HCl) is also used as anorexiant in obesity and to treat urinary incontinence.
Primary Characteristics
It is of Synthetic origin and belongs to Amine.
It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Decongestant pharmacological group. It is also classified under CNS Stimulant .
Molecular Weight: 187.7 · pKa: 9.4 · Solubility in Water: 1 in 2.5 · Solubility in Alcohol: 1 in 9 · Non-proprietary name: Phenylpropanolamine (HCl) · pH: 5.3 · Isotonic value: 2.6.
Pharmacokinetics
Absorption: Phenylpropanolamine (HCl) has an oral bioavailability is 92.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).
Elimination: plasma half-life is 3 -4 hr, renal excretion is > 90 %.
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Indications
Phenylpropanolamine (HCl) is primarily indicated in conditions like Appetite suppresser, Cold, Congestion, Cough, Urinary incontinence.
Contraindications
Phenylpropanolamine (HCl) is contraindicated in conditions like Glucoma, Hypertension, Hyperthyroidism, Prostatic hypertrophy, Intestinal obstruction.
Dosage
Phenylpropanolamine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 37.5 mg | 37.5 mg | Every 4h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Phenylpropanolamine (HCl) produces potentially life-threatening effects which include Hypertension. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Phenylpropanolamine (HCl) are Epileptic seizures, Hallucinations , Psychosis .
Phenylpropanolamine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Chest tightness, Dizziness, Headache, Nausea, Palpitation, Termors.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.25.2.3 — Cough sedatives
- 2.25.4 — Nasal preparations