Pheniramine (Maleate)

Also known as: Feniramin, Prophenpyridamine, Pheniraminum

Drug #561

Pheniramine (Maleate) is antihistamine. Pheniramine (Maleate) is effective in allergic rhinitis and allergic conjunctivitis, mild urticaria, angioedema, and in allergic reactions to blood and plasma in sensitive patients. Pheniramine (Maleate) is widely used as an ingredient in cold and cough preparations.

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Primary Characteristics

Pheniramine (Maleate) is also known as Feniramin, Prophenpyridamine, Pheniraminum.

It is of Synthetic origin and belongs to Alkylamine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant Combination pharmacological group.

Molecular Weight: 356.4 · pK_a: 4.2, 9.3 · Solubility in Water: 1 in 0.3 · Solubility in Alcohol: 1 in 2.5 · Non-proprietary name: Pheniramine (Maleate).

Molecular structure of Pheniramine (Maleate)

Pharmacokinetics

Absorption: Pheniramine (Maleate) has an oral bioavailability is 60.5% (±9.5%).

Distribution: Pheniramine (Maleate) has a volume of distribution is 230 litre.

Elimination: it is metabolised via Hepatic, plasma half-life is 16 - 19 hr, renal excretion is 33 - 43 %.

Indications

Pheniramine (Maleate) is primarily indicated in conditions like Allergy, Angioedema, Angiooedema, Asthma, Conjuctivitis, Dermatitis, Eczema, Hay fever, Perennial rhinitis, Rhinitis, Urticaria, Vasomotor rhinitis, Vertigo.

Contraindications

Pheniramine (Maleate) is contraindicated in conditions like Prostatic hypertrophy, Hypersensitivity.

Dosage

Pheniramine (Maleate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 – 150 mg	—	Every 24h		May be given twice daily
18.75 mg	18.75 mg	Every 12h	PO	initial dose, if necessary, may be increased upto 25 mg. Frequency may be increased to 3 times if needed.
Paediatric Dosage (20kg)
1.27 mg/kg	1.27 mg/kg	Every 24h	Intra Muscular	-
0.75 mg/kg	0.75 mg/kg	Every 8h	Oral	Dose for 1-3 Yrs of Children
Neonatal Dosage (3kg)
2 mg/kg	2 mg/kg	Every 24h	Intramuscular	For above 6 month of child

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pheniramine (Maleate) in overdosage may give rise to further complications which include Hallucinations .

The signs and symptoms that are produced after acute overdosage of Pheniramine (Maleate) are Hyperthermia, Sedation , Dry mouth, Hallucinations , Dizziness, Dermatitis , Toxic psychosis , Muscular weakness, Palpitations .

Pheniramine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Coordination disturbances, Dizziness, Dry mouth, Lassitude , Muscle weakness, nervousness, Sedation , Tachycardia, Tremors, Urinary retention.

Warnings / Precautions

Pheniramine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problems, high blood pressure, diabetes, thyroid disorder, heart disease, asthma or allergies, especially to sulfites. should not be coadminister in patient who are already on a MAOI therapy because MAOI intensify or prolong the cholinergic effect of antihistamine and therefore pheniramine should be avoided in such conditions.

Available Brands

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Single Ingredient

Inj

22.7 mg 22.7 mg/ml 25 mg/ml

Syrup

15 mg/5ml

Tabs

25 mg 50 mg 75 mg

Multi-Ingredient Combinations

Drops

Eye Drops

Powder

Sachet

Syrup

Syrup

Tabs

Storage Conditions

Pheniramine (Maleate) should be stored Tab.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
2.17.2 — Antiemetics & antinauseants
3.21.6 — Non-specific anticonjunctivitis preparations

Manufacturers

Manufacturers of Pheniramine (Maleate) in Pakistan: