Phenindione

Drug #560

Phenindione is a prothrombopenic anticoagulant drug with same action and uses as for dicumarol. Chemically Phenindione is 2-phenyl-1, 3-indandione. It has rapid onset of action and short duration of action. The actions are erratic and its short-duration of action is of little theraoeutic advantage.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenylindan.

It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.

Molecular Weight: 222.2 · pK_a: 4.1 · Solubility in Water: Insoluble · Solubility in Alcohol: 1 in 125 · Non-proprietary name: Phenindione.

Pharmacokinetics

Absorption: Phenindione has an oral bioavailability is 101%, pre-systemic (first-pass) metabolism accounts for 3% (±2%).

Distribution: Phenindione has a plasma protein binding is > 97 %.

Elimination: plasma half-life is 5 - 6 hr, renal excretion is exclusive.

Indications

Phenindione is primarily indicated in conditions like Deep vein thrombosis, Prevention of embolism, Prevention of thrombosis, Prophylaxis after insertion of prosthetic heart valve, Prophylaxis and treatment of venous thrombosis and pulmonary embolism, Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation, Pulmonary embolism.

Phenindione is also indicated for secondary conditions like Rheumatic heart disease.

Contraindications

None recorded.

Dosage

Phenindione's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.428 mg/kg	1.428 mg/kg	—	PO	Maintenance, as required
2.142 mg/kg	2.142 mg/kg	—	PO	Initial,for first 2 days
Paediatric Dosage (20kg)
2 mg/kg	2 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
2 mg/kg	2 mg/kg	Every 24h	Oral	-

Drug Interactions

Unknown9 interactions

2 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Phenindione in overdosage may give rise to further complications which include Fever , Hypersensitivity reactions , Renal impairment , Skin necrosis , Skin rashes .

Phenindione produces potentially life-threatening effects which include Blood dyscrasias, Bleeding , Hepatitis . Careful monitoring is needed with proper medical management.

Phenindione is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Skin reactions.

Warnings / Precautions

Phenindione should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits. Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K.Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teeth and use an electric razor. It should not be used during pregnancy or lactation.

Interference in Pathology

Phenindione may interfere in the diagnosis of Red Coloration of Urine .

Available Brands

None recorded.

Storage Conditions

Phenindione should be stored Tab.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators