Anistreplase

Drug #55

Anistreplase is a thrombolytic drug. It consists of a complex of purified human plasminogen and becterial streptokinase that has been acylated to protect the active site of the enzyme. It prevents blood from clotting. Anistreplase is used in the treatment of deep vein thrombosis and pulmonary embolism. Anistreplase is effective in reducing the risk of death following an acute heart attack.it may produce allergic recatuions.

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Primary Characteristics

It is of Synthetic origin and belongs to Polypeptide.

It belongs to Plasminogen Activator pharmacological group on the basis of mechanism of action and also classified in Thrombolytic Agent pharmacological group. It is also classified under Plasma Protein Fractions .

Molecular Weight: 59042.3 · pK_a: 7.61 · Non-proprietary name: Anistreplase.

Pharmacokinetics

Elimination: plasma half-life is 1.58 hr.

Indications

Anistreplase is primarily indicated in conditions like Myocardial infarction.

Contraindications

Anistreplase is contraindicated in conditions like Hypertension, Peptic ulcer, Cardiac stroke, Vaginal bleeding, Chest compresion, Intracranial neoplasm, Diabetic retinopathy, Hemorrhagic diathesis.

Dosage

Anistreplase's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 IU	30 IU	—	Slow IV	As Required
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Indicated in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recomended in this age group

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Anistreplase in overdosage may give rise to further complications which include Allergic reactions .

Anistreplase produces potentially life-threatening effects which include Bleeding . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Anistreplase are Hemorrhage .

Anistreplase is known to cause more or less tolerable side effects which are usually transient. These include Mild flushing, Shaking, Tight breathing.

Warnings / Precautions

Anistreplase should be used with caution in patients with bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120 or higher). This drug should be used with caution when the following conditions exist: child birth with in 10days, blood-clotting problems, retinal bleeding (recent) gastrointestinal or urinary tract bleeding (recent), ulcer, recent invasive medical procedure or any heart abnormalities.

Interference in Pathology

Anistreplase may interfere in the diagnosis of Decreased plasminogen level, Decreased fibrinogen level, Increased thrombin time.

Available Brands

None recorded.

Storage Conditions

Anistreplase should be stored Inj (reconstituted soln). Powder for Inj.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators
2.12.5 — Anti-thrombotic drugs and myocardial infarction