Pethidine (HCl)
Also known as: Meperidine
Pethidine (HCl) is a synthetic narcotic analgesic. The actions and adverse effects similar to that of morphine. Pethidine (HCl) is used to relieve severe pain. It is also an antispasmodic. It can produce coma with danger of death on overdosage. Naloxone is a specific antagonist. Tolerance or physical dependence may occur after a long-term use.
Primary Characteristics
Pethidine (HCl) is also known as Meperidine.
It is of Synthetic origin.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 247.33 · Non-proprietary name: Pethidine.
Pharmacokinetics
Distribution: Pethidine (HCl) has a plasma protein binding is 65-75%.
Elimination: it is metabolised via hepatic, plasma half-life is 3-5hours.
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Indications
Pethidine (HCl) is primarily indicated in conditions like Acute pain, Headache, Labor, Moderate to severe pain, Obsteteric analgesia, Obstetric pain, Pain, Parkinson's disease; drug-induced extrapyramidal symptoms, Post-operative shivering, Pre-anaesthetic medication, Severe pain and tenderness in benign fibrocystic breast disease, Surgery.
Pethidine (HCl) is also indicated for secondary conditions like All forms of epilepsy, Myoclonus.
Contraindications
Pethidine (HCl) is contraindicated in conditions like Asthma, Epilepsy, Phaeochromocytoma, Respiratory depression, Status epilepticus, Tetanus, Liver diseases, Raised intracranial pressure, Supraventricular tachycardia, Hypersensitivity, Kidney disease.
Dosage
Pethidine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | Every 4h | IM,SC | |
| Paediatric Dosage (20kg) | ||||
| 1.25 mg/kg | 1.25 mg/kg | Every 4h | Intra Muscular | - |
| 1.25 mg/kg | 1.25 mg/kg | Every 4h | Oral | |
| Neonatal Dosage (3kg) | ||||
| 1.5 | 1.5 | Every 4h | Intramuscular | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pethidine (HCl) in overdosage may give rise to further complications which include Myoclonus , GI symptoms, Dizziness , Vertigo , Hallucinations , Hypertension , Convulsions , Tachycardia , Hypotension , Skin rashes .
Pethidine (HCl) produces potentially life-threatening effects which include Coma, Respiratory depression, Convulsions , Hypotension, Dependence . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Pethidine (HCl) are Hypotension, Hallucinations , Mydriasis, Delirium, Tremor, CNS depression, Hypothermia, Bradycardia, Disorientation , Dry mouth, Respiratory depression, Cyanosis, Seizures.
Pethidine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Drowsiness, Dry mouth, Erythema, Fibrosis , Hypersensitivity , Light headedness, Malaise, Nausea, Nausea and vomiting, Pruritus , Twitching, Urticaria, Vomiting , Weakness.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics