Phenazocine (HBr)
Phenazocine (HBr) is a narcotic analgesic similar to morphine. Phenazocine (HBr) is used to relieve moderate to severe pain, with less sedation, vomiting and hypotension than morphine.
Primary Characteristics
It is of Synthetic origin and belongs to Opiate .
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 411.4 · pKa: 8.5 · Solubility in Water: 1 in 350 · Solubility in Alcohol: 1 in 45 · Non-proprietary name: Phenazocine (HBr).
Pharmacokinetics
Distribution: Phenazocine (HBr) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Phenazocine (HBr) is primarily indicated in conditions like Pain.
Contraindications
Phenazocine (HBr) is contraindicated in conditions like Alcohol dependence, Convulsions, Respiratory depression, Delirium tremens, Coma, Obstructive airway disease, Myxedema.
Dosage
Phenazocine (HBr)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.178 mg/kg | 0.178 mg/kg | Every 6h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Doses not established for children | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Phenazocine (HBr) in overdosage may give rise to further complications which include Dependency .
The signs and symptoms that are produced after acute overdosage of Phenazocine (HBr) are Respiratory depression.
Phenazocine (HBr) is known to cause more or less tolerable side effects which are usually transient. These include Nausea, Pruritus , Respiratory depression, Vomiting .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics