Amsacrine

Also known as: Acridinyl Anisidide

Drug #54

Amsacrine is the antineoplastic agent, also called anticancerou drug. Amsacrine is a 9-anilinoacridine derivative. Amsacrine is effective in the treatment of different cancers to slow or stop the growth of abnormal cells. Amsacrine is used in combination with different anticancerous drugs to obtain most excellent therapeutic effects and to minimize unwanted effects or toxicities.

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Primary Characteristics

Amsacrine is also known as Acridinyl Anisidide.

It is of Synthetic origin and belongs to Sulphonamide.

It belongs to DNA Strand Breakage pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent pharmacological group. It is also classified under Chemotherapeutic Regimens .

Molecular Weight: 393.5 · Non-proprietary name: Amsacrine.

Pharmacokinetics

Distribution: Amsacrine has a volume of distribution is 70-126 l/sq.meter. plasma protein binding is 98%.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 3.3-6.3 hr, renal excretion is less.

Indications

Amsacrine is primarily indicated in conditions like Myelogenous leukaemia, Refractory acute non-lymphocyte leukemia.

Contraindications

Amsacrine is contraindicated in conditions like Hypokalaemia, Pregnancy, Breast feeding.

Dosage

Amsacrine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mg/sq.meter	500 mg/sq.meter	Every 24h	IV	For 5 Days, Repeated after 3-4 Weeks
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Amsacrine in overdosage may give rise to further complications which include Anemia , Thrombocytopenia , Hepatotoxicity , Mucositis .

Amsacrine produces potentially life-threatening effects which include Bone marrow aplasia, Arrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Amsacrine are Bone marrow suppression.

Amsacrine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Confusion, Diarrhea, Dizziness, Headache, Mucositis, Myelosuppression, Nausea, Perirectal abscess, Pruritus , Rashes , Stomatitis, Urticaria, Vomiting .

Warnings / Precautions

Amsacrine is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes and should not be inhaled.

Available Brands

None recorded.

Storage Conditions

Amsacrine should be stored Inj.

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs