Pamidronate (Disodium Pentahydrate)
Chemically Pamidronate (Disodium Pentahydrate) is (3-amino-1-hydroxypropylidene) biphosphonic acid disodium salt pentahydrate. It reduces the blood calcium levels in tumour-induced hypercalcemia to has a slow onset of action so is not suitable for initial treatment of severe hypercalacaemia . It inhibits resorption, so is used to treat Paget's disease of bone. Pamidronate (Disodium Pentahydrate) is also used in the treatment of osteoporosis, to reduce bone pain associated with myeloma and breast cancer. Pamidronate (Disodium Pentahydrate) is prepaed by chemical synthesis and available in any combination preparations. Pamidronate (Disodium Pentahydrate) is administered intravenously.
Primary Characteristics
It is of Synthetic origin and belongs to Biphosphate.
It belongs to Osteoclast inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.
Molecular Weight: 367 · pKa: 0.1, 6.2, 10.9 · Solubility in Water: 1 in 30 · Non-proprietary name: Pamidronate (Disodium Pentahydrate).
Pharmacokinetics
Absorption: Pamidronate (Disodium Pentahydrate) has an oral bioavailability is 15.5% (±4.5%).
Distribution: Pamidronate (Disodium Pentahydrate) has a volume of distribution is 0.5 - 0.6 l/kg. plasma protein binding is < 14 %.
Elimination: plasma half-life is 0.5 hr, renal excretion is 50 %.
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Indications
Pamidronate (Disodium Pentahydrate) is primarily indicated in conditions like Bone (pagets) disease, Hypercalcaemia, Osteoporosis, Thyrotoxicosis.
Pamidronate (Disodium Pentahydrate) is also indicated for secondary conditions like Bone metastasis.
Contraindications
Pamidronate (Disodium Pentahydrate) is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Pamidronate (Disodium Pentahydrate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 60 mg | 60 mg | — | IV | Once or As Required |
| 200 mg | 200 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pamidronate (Disodium Pentahydrate) in overdosage may give rise to further complications which include Fever , Acute phase response .
Pamidronate (Disodium Pentahydrate) is known to cause more or less tolerable side effects which are usually transient. These include Hypocalcemia, Hypophosphatemia.
Warnings / Precautions
Interference in Pathology
Pamidronate (Disodium Pentahydrate) may interfere in the diagnosis of Hematocrit Value , Complete blood cell count.
Available Brands
Storage Conditions
Drug Classification
- 1.18.14 — Drugs affecting bone metabolism