Pancuronium (Br)
Pancuronium is a competitive neuromuscular blocking agent used during surgical procedures. Chemically Pancuronium (Br) is identified as 1,1-[3,17-bis (acetyloxy) androstane-2,16-diyl] bis (1-methylpiperidinium) dibromide. It has two acetylcholine like molecules in 2-3 and 16-17 positions on the steroid nucleus. Pancuronium (Br) is prepared by chemical synthesis. Pancuronium (Br) is administered parentrally.
Primary Characteristics
It is of Synthetic origin and belongs to Acetylcholine.
It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Neuromuscular Blocking Agent, Nondepolarizing pharmacological group. It is also classified under Muscle Relaxants .
Molecular Weight: 732.7 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Pancuronium (Br).
Pharmacokinetics
Absorption: Pancuronium (Br) has an oral bioavailability is 0.5% (±0.5%).
Distribution: Pancuronium (Br) has a volume of distribution is 0.21 - 0.37 l/kg. plasma protein binding is 30 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 32 min, renal excretion is 55 - 70 % (unchanged).
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Indications
Pancuronium (Br) is primarily indicated in conditions like Induce neuromuscular blokage, Muscle relaxation (long duration) during intensive care, Muscle relaxation (long duration) for surgery and intubation.
Contraindications
Pancuronium (Br) is contraindicated in conditions like Anuria.
Dosage
Pancuronium (Br)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.015 mg/ kg | 0.015 mg/ kg | — | IV | Incremental Dose. Overdosage should be avoided in obese patient. |
| 0.04 mg/ kg | 0.04 mg/ kg | — | IV | Initial Dose |
| Paediatric Dosage (20kg) | ||||
| 0.06 ug/kg | 0.06 ug/kg | — | Intra Venous | Initially for Once |
| 15 ug/kg | 15 ug/kg | — | Intra Venous | Maintenance every 30 to 60 min, As Required |
| Neonatal Dosage (3kg) | ||||
| 0.06 ug/kg | 0.06 ug/kg | — | Intra Venous | Initially for Once |
| 15 ug/kg | 15 ug/kg | — | Intra Venous | Maintenance every 30 to 60 min, As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Pancuronium (Br) is known to cause more or less tolerable side effects which are usually transient. These include Hypertension , Tachycardia.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors