Oral Rehydration Salts (ORS)

Also known as: ORS

Drug #534

Oral redyration salt is used for oral replacement of electrolytes and fluids in patient with dehydration associated with diarrohea. The main constitutes oral rehydration salt are anhydrous dextrose, sodium chloride, potassium chloride and either trisodium citrate dihydrate or sodium bicarbonate. The simple glucose electrolyte solutions can adequately rehydrate patients. Oral Rehydration Salts is one of the major therapeutic advances of this century and since 1960s it has saved the lives of millions of children. It has become the manistay of treatment for the dehydration and acidosis associated with acute infectious diarrohea.

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Primary Characteristics

Oral Rehydration Salts (ORS) is also known as ORS.

It is of Synthetic origin and belongs to Salts.

It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action and also classified in Electrolyte Oral pharmacological group.

Non-proprietary name: Oral Rehydration Salts (ORS).

Molecular structure of Oral Rehydration Salts (ORS)

Pharmacokinetics

None recorded.

Indications

Oral Rehydration Salts (ORS) is primarily indicated in conditions like Acute infectious diarrhoea, Dehydration, Diarrhoea, Fluid and electrolyte loss in diarrhoea, Fluid depletion, Rehydration of patient with burns.

Contraindications

Oral Rehydration Salts (ORS) is contraindicated in conditions like Continued vomiting, Severe dehydration.

Dosage

Oral Rehydration Salts (ORS)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 – 400 ml	—	—	PO	During 24 hrs., As required
Paediatric Dosage (20kg)
0.042 Litrtes/kg	0.042 Litrtes/kg	—	Oral	During 24 hrs., As required
Neonatal Dosage (3kg)
0.042 Litrtes/kg	0.042 Litrtes/kg	—	Oral	During 24 hrs., As required

Drug Interactions

None recorded.

Side Effects

Oral Rehydration Salts (ORS) in overdosage may give rise to further complications which include Radiosensitization effect on thorax, Skin inflammation, Esophageal inflammation.

Oral Rehydration Salts (ORS) produces potentially life-threatening effects which include Hyperkalemia , Hypernatremia, Hyperkalemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Oral Rehydration Salts (ORS) are Severe vomiting, Mucositis, Diarrhea, Severe myelosuppression, Hyperkalemia, Hypernatremia.

Oral Rehydration Salts (ORS) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Alopecia, Diarrhea, Fever, Mucositis, Myalgia, Nausea, Reaction at injection site, Vomiting .

Warnings / Precautions

Use with caution in patients with pre-existing blood disorders, gout, dental disease, liver disease or heart disease. This medication is classified as pregnancy category C and should be used during pregnancy or lactation only if clearly needed. These are not appropiate for patients with gartrointestinal obstruction, oliguric or anuric renal failure oral rehydration salts should be reconstituted only with water.

Interference in Pathology

Oral Rehydration Salts (ORS) may interfere in the diagnosis of Bioassay procedures for determination of antibacterial drug levels. .

Available Brands

None recorded.

Storage Conditions

Oral Rehydration Salts (ORS) should be stored Solution, Syrup, Powder.

Drug Classification

1.17.7.1 — Oral rehydration
2.26.1.1 — Oral rehydration salt (ORS)