Olsalazine (Na)

Also known as: Azodisal Na

Drug #531

Olsalazine (Na) is a sulfa free drug based on 5-aminosalicyclic acid. It consist of 5-aminosalicylic acid joined together through an azo bond. It acts locally in the colon by delivery of two 5-ASA molecules after splitting of the azo-bond to relieve the inflammation. Olsalazine (Na) is used to treat and prevent relapse of ulcerative colitis. Olsalazine (Na) is prepared by chemical syhthesis. Olsalazine (Na) is administered orally.

← Previous drug Next drug →

Primary Characteristics

Olsalazine (Na) is also known as Azodisal Na.

It is of Synthetic origin and belongs to Aminosalicylic Acid.

It belongs to Ulcerative Colitis remedies (GI) pharmacological group on the basis of mechanism of action and also classified in Antipeptic Ulcerant pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 346.2 · pK_a: 2.07, 11.5 · Solubility in Water: Sparingly soluble · Solubility in Alcohol: 1 in 10000 · Non-proprietary name: Olsalazine (Na).

Pharmacokinetics

Absorption: Olsalazine (Na) has an oral bioavailability is 2% (±1%).

Distribution: Olsalazine (Na) has a volume of distribution is 6 litre. plasma protein binding is 99.8 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 56 min, renal excretion is 20 %.

Indications

Olsalazine (Na) is primarily indicated in conditions like Ulcerative colitis.

Contraindications

Olsalazine (Na) is contraindicated in conditions like Hypersensitivity.

Dosage

Olsalazine (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 – 3 g	—	—	PO	Initial Dose
0 – 42.857 kg	—	Every 24h	PO
500 mg	500 mg	Every 12h	PO	Maintanance dose
Paediatric Dosage (20kg)
225 mg/kg	225 mg/kg	Every 24h	Oral	For above 2 Yrs of children
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Olsalazine (Na) in overdosage may give rise to further complications which include Pancreatitis .

Olsalazine (Na) produces potentially life-threatening effects which include Bone marrow suppression, Lupus like Syndrome. Careful monitoring is needed with proper medical management.

Olsalazine (Na) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Alopecia, Arthralgia, Diarrhoea, dizziness, Headache, Light headedness, Loose stools, Nausea, Rashes .

Warnings / Precautions

Olsalazine should be used only if clearly needed during pregnancy. It should be used with caution in patients with allergies especially to aspirin or aspirin-like medications or if have a history of nasal polyps or asthma. It can increase sensitivity to sunlight, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen.

Available Brands

None recorded.

Storage Conditions

Olsalazine (Na) should be stored Caps. .

Drug Classification

1.17.4 — Anti-inflammtory drugs