DrugInfoSys

Ofloxacin

Drug #530

.

← Previous drugNext drug →

Primary Characteristics

It is of Semi Synthetic origin and belongs to Quinolone.

It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Quinolone pharmacological group.

Molecular Weight: 361.38 · pKa: 7.9 · Solubility in Water: poorly soluble · Solubility in Alcohol: poorly soluble · Non-proprietary name: Ofloxacin.

Molecular structure of Ofloxacin

Pharmacokinetics

Absorption: Ofloxacin has an oral bioavailability is 100%.

Distribution: Ofloxacin has a volume of distribution is 1-2.5 l/kg. plasma protein binding is 20-25%.

Elimination: it is metabolised via hepatic, plasma half-life is 4.9-6.9 hr, renal excretion is 80%.

Advertisement

Indications

Ofloxacin is primarily indicated in conditions like Acute uncomplicated cystitis, Bronchitis, Chronic prostatitis, Complicated UTIS, Corneal ulcers, Diabetic foot ulcer, GI infections, Lower RTIs, Meningococal infections, Opthalmic infections, Otitis externa, Otitis media, Pelvic inflammatory disease, Pneumonia, Prostatitis, Pulmonary infection, Septicaemia, Sexually transmitted infections, Skin and soft tissue infections, Travelers diarrhoea, Uncomplicated genital chlamydial infection, non-gonococcal urethritis, Urinary tract infection.

Ofloxacin is also indicated for secondary conditions like Conjuctivitis, Osteomyelitis, Skin infections, Soft tissue infections.

Contraindications

Ofloxacin is contraindicated in conditions like Hypersensitivity.

Dosage

Ofloxacin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.3 %0.3 %Every 6hOphthalmic,Otic
350 mg350 mgEvery 12hPO,IV
Paediatric Dosage (20kg)
0 – 0——Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

Unknown7 interactions
Minor1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ofloxacin in overdosage may give rise to further complications which include Sinus tachycardia , Hallucinations , Hallucinations , Stevens johnson syndrome , Stevens johnson syndrome , Seizures , Tendon rupture.

Ofloxacin produces potentially life-threatening effects which include Agranulocytosis, Anaphylaxis . Careful monitoring is needed with proper medical management.

Ofloxacin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dizziness, GI upset, Headache, Hypotension, Insomnia, Nausea, Photosensitivity, Pruritus , Vomiting .

Warnings / Precautions

Ofloxacin should be used with caution in patients with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergies, including drug allergies. It should be used with caution while driving or performing tasks requiring alertness because this medication causes dizziness, lightheaded or drowsiness. Limit alcohol intake. Because this increase sensitivity to the sun, avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. Caution is advised when used in children under 18 years of age. It should be used only when clearly needed during pregnancy. Avoid use during lactation. Prolonged use may result in overgrowth of non-susceptible organisms. Caution is required in patients hypersensitive to other quinolones. Care is also required as ofloxacin is systemically absorbed after topical administration.

Interference in Pathology

Ofloxacin may interfere in the diagnosis of False-positive urine screening results, False-positive urine screening results.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps
200 mg
Ear Drops
0.3 %w/v
Ear Drops
0.6 %w/v
Eye Drops
0.3 %w/v3 mg/ml
Eye Oint
0.3 %w/w
Inf
200 mg200 mg/100200 mg/100ml
Inj
200 mg/100ml500 mg/10ml
Oint
0.3 %w/w
Tabs
200 mg400 mg

Multi-Ingredient Combinations

Eye Drops
0.3 %w/v

Storage Conditions

Ofloxacin should be stored Eye Soln. Inj (Reconstituted soln). Tab.

Drug Classification

  1. 1.6.2.2.2 — Quinolones

Manufacturers

Manufacturers of Ofloxacin in Pakistan:

AdamjeeAdfaAdvancedAhadAkhaiAksonAlbroAlinaAlkemyAllianceAmbrosiaAnkazAptcureAtcoAventisAxisAzron PharmaBarrettBasel BatalaBiogenBiolabsBiorexBloomBoschBrookesBryonCandidCCLCibexCirinCityCombatDanasDavisDeltaDon valleyDosacoDr.RazaDrugsDyson R LE PharmEG PharmaElkoEnglishEnvoyEpochErosEverestEvergreenF.MFassgenFerozsonFerrozaFozanFriendsFrontierFynkGabaGeneraGenomeGeofmanGlobalGoodman LGray'sGSKHamazHanselHarmannHealHeliconHelixHigh-QHiltonHimont PharmaHisunHizatHonigHygeiaIdealIndusIrzaISISJawaJinnahKobecLawrenceLeamaLinearLiskoLowittMac & RansMacquinsMacterMarionMassMederaMediceenaMediconMedicraftMedifineMEDISAVEMedisureMeditechMega PharmaMiracleNabiqasimNenzaNeoNeutroNimrallNoa HemisNovamedObsonsOlive LabsOphth-PharmaOrtaPakheimPanaceaParamountPDHPharmacarePharmatecPlatinumPlivaPolyfinePPPPulseRaazeeRakaposhiRascoRegentRehmanRekoRemingtonRockRoryan PharmaRoyal ConsumerSaffronSafinaSanteSaturnSaydonSayyadSchazooScotmannShaheen PharmaShawanShazalShrooqSilverSizaSpencerStalwartStandardStandpharmSwanSyntexTabrosTagmaUmersonsUnexoUnisonValorVegaVentureVisionWebroseWellWelmarkWerrickWilshireWilsonsWiseWnsFeildZ-JansZafaZanctokZephyrZesionZintaZumars