Estradiol.
Also known as: Oestradiol,
Estradiol is a naturally occuring sex hormone (oestrogen). estradiol is used along with progesterone for contraception, menstrual disorder, and for the suppression of certain cancers and also for the prevention of osteoporosis.
Primary Characteristics
Estradiol. is also known as Oestradiol, .
It is of Natural origin and belongs to Steroid.
It belongs to Oestrogen Agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 272.4 · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 28 · Non-proprietary name: Estradiol..
Pharmacokinetics
Absorption: Estradiol. has an oral bioavailability is 60.5% (±9.5%), pre-systemic (first-pass) metabolism accounts for 83% (±7%).
Distribution: Estradiol. has a volume of distribution is 9-5 liters. plasma protein binding is 97 - 99 %.
Elimination: it is metabolised via Gut wall and Hepatic, plasma half-life is 20-70 min, renal excretion is 80 %.
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Indications
Estradiol. is primarily indicated in conditions like Menopausal symptoms, Prostatic cancer.
Contraindications
Estradiol. is contraindicated in conditions like Hypertension, Vaginal bleeding, Porphyrias, Cardiovascular disease, Oestrogenic sarcoma, Cerebrovascular disease, Haemoglobinopathies, Hyperlipoproteinaemia.
Dosage
Estradiol.'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg | 1.5 mg | Every 24h | PO | Normally given in 21 day cycles |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Estradiol. in overdosage may give rise to further complications which include Irritability , Gynacomastia , Uterine bleeding , Tachyphylaxis.
Estradiol. produces potentially life-threatening effects which include Endometrial carcinoma, Breast cancer. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Estradiol. are Vomiting, Dizziness, Headache, Speech problem, Breast Lump, Redness in one leg, Chest crushing pain, Shortness of breath, Double Vision, Coughing up blood.
Estradiol. is known to cause more or less tolerable side effects which are usually transient. These include Breast tenderness, Depression, Fluid retention, Headache, Nausea and vomiting, Weight gain.
Warnings / Precautions
Interference in Pathology
Estradiol. may interfere in the diagnosis of Thyroid Function Test , Plasma Cortisol Test , Urinary 17-Oxogenic Steroid Test .
Available Brands
Storage Conditions
Drug Classification
- 1.18.4 — Estrogens, their combinations and related preparations