Nystatin
Also known as: Fungicidin, nystatin also known as fungicidin
Nystatin is antifungal agent obtained from Streotomyces noursei. It was one of the first polyene antibiotic of undetermined structure, discovered and used clinicaly. It acts as a fungistatic and fungicidal and active against most Candida species. Nystatin is a mixture of four different tetranes, primarily it A1, along with two other tetranes A2 or A3 and polyfungin B. Nystatin is very toxic for parentral administration and is only used topically.
Primary Characteristics
Nystatin is also known as Fungicidin, nystatin also known as fungicidin.
It is of Semi Synthetic origin and belongs to Polyene.
It is classified in Antifungal Agent, Topical pharmacological group.
Molecular Weight: 926 · pKa: 4.5, 8.64 · Solubility in Water: very low · Solubility in Alcohol: Partically insoluble · Non-proprietary name: Nystatin.
Pharmacokinetics
None recorded.
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Indications
Nystatin is primarily indicated in conditions like Candidiasis, Fungal infection, Intestinal candidiasis, Oral and perioral fungal infections.
Nystatin is also indicated for secondary conditions like Vaginal infections.
Contraindications
None recorded.
Dosage
Nystatin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100000 – 600000 IU | — | Every 24h | Buccal | Preferably 2-4 times a day. |
| Paediatric Dosage (20kg) | ||||
| 100000 IU/gm | 100000 IU/gm | Every 8h | Buccal | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Nystatin are Nephrotoxicity .
Nystatin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Contact dermatitis, Diarrhea, Nausea, Rashes , Skin irritation, Stevens Johnson syndrome, Urticaria, Vomiting .
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.6.3 — Antifungal drugs
- 2.28 — Otic drugs