Netilmicin (Sulphate)
Also known as: Netillin, Netromycin, Nettacin
Netilmicin is a semisynthetic aminoglycoside antibiotic derived from sisomicin, having a range of antibacterial activity similar to that of gentamicin and tobramycin. The sulphate salt of netilmicin, administered intramuscularly and intravenously in the treatment of wide variety of infections caused by susceptible gram-negative organism. Netilmicin (Sulphate) is active alone but also exhibit synergism with ß lactam antibiotic. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Netilmicin (Sulphate) is important to take the drug for the full time period as prescribed. Discontinuation of the therapy may result in ineffective treatment.
Primary Characteristics
Netilmicin (Sulphate) is also known as Netillin, Netromycin, Nettacin.
It is of Semi Synthetic origin and belongs to Aminoglycosides.
It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action.
Molecular Weight: 1441.6 · pKa: 8.1 · Solubility in Water: soluble · Non-proprietary name: Netilmicin (Sulphate).
Pharmacokinetics
Absorption: Netilmicin (Sulphate) has an oral bioavailability is 15.5% (±4.5%).
Distribution: Netilmicin (Sulphate) has a volume of distribution is 0.27 l/kg. plasma protein binding is low.
Elimination: plasma half-life is 2.5 hr, renal excretion is 150mg/l a/f 2mg/kg dose.
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Indications
Netilmicin (Sulphate) is primarily indicated in conditions like Advanced breast cancer in postmenopausal women, Bacterial infections, Gonorrhoea, Heart failure, Joint infections, Septicaemia, Serious gram -ve infections resistant to gentamicin, Supraventricular arrhythmias (particularly atrial fibrillation), Surgical infections, Urinary tract infection, UTI.
Contraindications
None recorded.
Dosage
Netilmicin (Sulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg/kg | 5 mg/kg | — | IV,IM, PO | As a single dose. Dose may be increased upto 7.5 mg/kg/day in 2 divided doses, depending on the severity and location of infection. |
| Paediatric Dosage (20kg) | ||||
| 2.142 mg/kg | 2.142 mg/kg | Every 12h | Intra Muscular | For 3 to 5 minutes |
| 2.142 mg/kg | 2.142 mg/kg | Every 12h | Intra Venous | For 3 to 5 minutes |
| Neonatal Dosage (3kg) | ||||
| 2.142 mg/kg | 2.142 mg/kg | Every 12h | Intra Muscular | For 3 to 5 minutes |
| 2.142 mg/kg | 2.142 mg/kg | Every 12h | Intra Venous | For 3 to 5 minutes |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Netilmicin (Sulphate) in overdosage may give rise to further complications which include Nephrotoxicity , Ototoxicity .
Netilmicin (Sulphate) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
Netilmicin (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Elevated hepatic transaminases, Maculopapular rash, Nausea, Pain , Phlebitis , Urticaria, Vomiting .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.2.5 — Aminoglycosides