Nabumetone

Also known as: Nabumetona, Nabumetona

Drug #496

Nabumetone is a nonsteroidal anti-inflammatory drug. Chemically Nabumetone is identified as 4-( 6-methoxy-2-naphthalenyl)-2-butanone. Nabumetone is given by mouth in osteoarthritis and rheumatoid arthritis. The drug itself is a relatively weak inhibitor of prostaglandin synthesis, but Nabumetone is metabolized in the liver to a more active compound. May thus cause less gastro-intestinal irritation than some other drugs in this class such as indomethacin, but is still contraindicated if there is a history of peptic ulceration.

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Primary Characteristics

Nabumetone is also known as Nabumetona, Nabumetona.

It is of Synthetic origin and belongs to Napthyl Butane.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 228.3 · Solubility in Water: Insoluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Nabumetone · pH: 7.4.

Pharmacokinetics

Absorption: Nabumetone has an oral bioavailability is 80%, pre-systemic (first-pass) metabolism accounts for 100%.

Distribution: Nabumetone has a volume of distribution is 7.5 l/kg. plasma protein binding is 99 %.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 22 hr, renal excretion is 80 %.

Indications

Nabumetone is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Osteoarthritis, Pain, Pain and inflammation in rheumatoid arthritis, Rheumatoid arthritis.

Nabumetone is also indicated for secondary conditions like Ankylosing spondylitis, Soft tissue rheumatism.

Contraindications

Nabumetone is contraindicated in conditions like Peptic ulcer.

Dosage

Nabumetone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1000 mg	1000 mg	Every 24h	PO	At bed time
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Nabumetone in overdosage may give rise to further complications which include Cholestatic jaundice , Complications of GI ulcerations.

Nabumetone is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Flatulence, Increased intracranial pressure, Nausea.

Warnings / Precautions

Nabumetone should be used with caution in patients with any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies, especially drug allergies. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Caution is advised when this drug is used in the elderly. This medication should be used during pregnancy or lactation only if clearly needed. Use of this drug in the last 6 months of pregnancy is not recommended.

Available Brands

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Single Ingredient

Tabs

500 mg

Storage Conditions

Nabumetone should be stored Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers

Manufacturers of Nabumetone in Pakistan:

Genome GSK